Abstract
To determine the most appropriate terminology for neuroendocrine carcinomas (NEC) of the larynx, successive clinicopathologic studies are encouraged. The typical location and immunophenotype of laryngeal NEC raise a question of whether any precursor cells exist. Six patients with laryngeal NEC were analyzed. Another 20 laryngectomy specimens were examined for the presence of non-neoplastic neuroendocrine cells. Tumor morphology and patient outcome were determined, and tumor tissue underwent immunohistochemical examination to identify cytokeratin, neuroendocrine markers (chromogranin, synaptophysin, CD56, calcitonin), S-100 protein, and p53 protein. A neuroendocrine marker study was also performed on non-neoplastic regions of another 20 laryngectomy specimens to identify any neuroendocrine cells. Laryngeal NEC, all submucosal, exhibited various morphology with or without histologic evidences of neuroendocrine differentiation. The tumors showed frequent (67%) calcitonin expression, calcitonin secretion in one case, and common (50%) p53 over-expression. Three patients died within 3 years. In the non-neoplastic larynx specimens, Kulchitsky cell-like bipolar neuroendocrine cells were identified in the basal and middle layer of the r...Continue Reading
References
Mar 1, 1991·Histopathology·C M MilroyE Moss
Dec 1, 1991·The Journal of Laryngology and Otology·J P LogueS Vasanthan
Nov 1, 1991·Head & Neck·I I Moisa
Jan 1, 1991·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·J M Woodruff, R T Senie
Aug 1, 1991·The Journal of Laryngology and Otology·A K el-NaggarM A Luna
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·G SmetsG Klöppel
Nov 1, 1985·The American Journal of Surgical Pathology·J M WoodruffF P Gerold
Dec 15, 1988·Cancer·B M WenigD K Heffner
Jul 1, 1984·Acta Oto-laryngologica·C PesceC Toncini
Aug 1, 1995·The Laryngoscope·S M OverholtB R Alford
Jul 1, 1993·Histopathology·S A SalimQ Hamid
May 1, 1995·The Journal of Laryngology and Otology·G W Watters, A J Molyneux
Mar 1, 1994·The Journal of Laryngology and Otology·U SchmidtL D Leder
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Y C YuT Shin
Sep 1, 1997·Ultrastructural Pathology·W G McCluggageP G Toner
Jan 1, 1997·The Journal of Laryngology and Otology·C EreñoJ M Sanchez
Jul 4, 1998·Regulatory Peptides·C Hauser-KronbergerO Dietze
Jan 7, 1999·The Journal of Laryngology and Otology·A FerlitoC M Milroy
Jul 7, 1999·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A MachensH Dralle
Dec 29, 2000·Histochemistry and Cell Biology·Y YamamotoY Suzuki
Jun 22, 2001·Experimental and Molecular Pathology·R Yesner
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stacey E Mills
May 10, 2002·Acta otorrinolaringológica española·V Jiménez OliverG Rodríguez Baró
May 22, 2002·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Alfio FerlitoAlessandra Rinaldo
Citations
Jul 1, 2010·Head and Neck Pathology·James S LewisSamir K El-Mofty
Sep 13, 2005·Oral Oncology·Alfio Ferlito, Alessandra Rinaldo
May 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio FerlitoAlessandra Rinaldo
Jul 1, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kenneth O DevaneyAlessandra Rinaldo
Feb 18, 2016·Medicine·Kui-Rong WangJun Fan
Jul 12, 2008·Auris, Nasus, Larynx·Giovanna GiordanoTeore Ferri
Jun 10, 2008·Annales de pathologie·Mohamed OukabliFranck Fetissof
Jul 5, 2005·The Laryngoscope·Ann GillenwaterAdel El-Naggar
May 11, 2011·The Laryngoscope·James S LewisUNKNOWN International Head and Neck Scientific Group
Jul 4, 2006·Oral Oncology·Alfio FerlitoAlessandra Rinaldo
Mar 7, 2014·Head & Neck·Tom P van der LaanGyorgy B Halmos
Oct 26, 2011·Oral Oncology·Kimihide KusafukaLeon Barnes
May 13, 2009·Clinical and Experimental Otorhinolaryngology·Eun-Jae ChungKwang-Yoon Jung
Mar 21, 2018·Head and Neck Pathology·Bayardo Perez-Ordoñez
Jun 19, 2018·The Journal of Laryngology and Otology·F LópezA Ferlito
Mar 25, 2017·Advances in Anatomic Pathology·Jennifer L HuntAntonio Cardesa
Aug 9, 2020·Frontiers in Endocrinology·Tiziana FeolaElisa Giannetta
Dec 1, 2015·Nihon Jibiinkoka Gakkai kaiho·Yoshinori KadowakiMasashi Suzuki
Dec 2, 2017·Journal of Cutaneous Pathology·Andrew DunnSara C Shalin
Apr 30, 2019·Advances in Anatomic Pathology·Jennifer L HuntAlfio Ferlito
Aug 23, 2019·Cancer Treatment Reviews·Primož StrojanAlfio Ferlito
Mar 5, 2021·Frontiers in Oncology·Ouying YanFeng Liu
Jul 1, 2006·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·K Salil KumarC V Vivek
Aug 6, 2021·Laryngo- rhino- otologie·Stephan HackenbergAgmal Scherzad