A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells

The Laryngoscope
Jin-Haeng ChungKyung-Ja Cho

Abstract

To determine the most appropriate terminology for neuroendocrine carcinomas (NEC) of the larynx, successive clinicopathologic studies are encouraged. The typical location and immunophenotype of laryngeal NEC raise a question of whether any precursor cells exist. Six patients with laryngeal NEC were analyzed. Another 20 laryngectomy specimens were examined for the presence of non-neoplastic neuroendocrine cells. Tumor morphology and patient outcome were determined, and tumor tissue underwent immunohistochemical examination to identify cytokeratin, neuroendocrine markers (chromogranin, synaptophysin, CD56, calcitonin), S-100 protein, and p53 protein. A neuroendocrine marker study was also performed on non-neoplastic regions of another 20 laryngectomy specimens to identify any neuroendocrine cells. Laryngeal NEC, all submucosal, exhibited various morphology with or without histologic evidences of neuroendocrine differentiation. The tumors showed frequent (67%) calcitonin expression, calcitonin secretion in one case, and common (50%) p53 over-expression. Three patients died within 3 years. In the non-neoplastic larynx specimens, Kulchitsky cell-like bipolar neuroendocrine cells were identified in the basal and middle layer of the r...Continue Reading

References

Mar 1, 1991·Histopathology·C M MilroyE Moss
Dec 1, 1991·The Journal of Laryngology and Otology·J P LogueS Vasanthan
Nov 1, 1991·Head & Neck·I I Moisa
Jan 1, 1991·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·J M Woodruff, R T Senie
Aug 1, 1991·The Journal of Laryngology and Otology·A K el-NaggarM A Luna
Nov 1, 1985·The American Journal of Surgical Pathology·J M WoodruffF P Gerold
Jul 1, 1984·Acta Oto-laryngologica·C PesceC Toncini
Aug 1, 1995·The Laryngoscope·S M OverholtB R Alford
May 1, 1995·The Journal of Laryngology and Otology·G W Watters, A J Molyneux
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Y C YuT Shin
Jan 1, 1997·The Journal of Laryngology and Otology·C EreñoJ M Sanchez
Jan 7, 1999·The Journal of Laryngology and Otology·A FerlitoC M Milroy
Jul 7, 1999·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A MachensH Dralle
Dec 29, 2000·Histochemistry and Cell Biology·Y YamamotoY Suzuki
Jun 22, 2001·Experimental and Molecular Pathology·R Yesner
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stacey E Mills
May 10, 2002·Acta otorrinolaringológica española·V Jiménez OliverG Rodríguez Baró
May 22, 2002·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Alfio FerlitoAlessandra Rinaldo

❮ Previous
Next ❯

Citations

Jul 1, 2010·Head and Neck Pathology·James S LewisSamir K El-Mofty
Sep 13, 2005·Oral Oncology·Alfio Ferlito, Alessandra Rinaldo
May 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio FerlitoAlessandra Rinaldo
Jul 1, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kenneth O DevaneyAlessandra Rinaldo
Jun 10, 2008·Annales de pathologie·Mohamed OukabliFranck Fetissof
May 11, 2011·The Laryngoscope·James S LewisUNKNOWN International Head and Neck Scientific Group
Oct 26, 2011·Oral Oncology·Kimihide KusafukaLeon Barnes
May 13, 2009·Clinical and Experimental Otorhinolaryngology·Eun-Jae ChungKwang-Yoon Jung
Jun 19, 2018·The Journal of Laryngology and Otology·F LópezA Ferlito
Mar 25, 2017·Advances in Anatomic Pathology·Jennifer L HuntAntonio Cardesa
Dec 1, 2015·Nihon Jibiinkoka Gakkai kaiho·Yoshinori KadowakiMasashi Suzuki
Aug 23, 2019·Cancer Treatment Reviews·Primož StrojanAlfio Ferlito
Jul 1, 2006·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·K Salil KumarC V Vivek
Aug 6, 2021·Laryngo- rhino- otologie·Stephan HackenbergAgmal Scherzad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
R Dieler, J Dämmrich
© 2022 Meta ULC. All rights reserved