A study of monoamine metabolism in human epilepsy.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
D LouwJ Girvin

Abstract

Fourteen patients with intractable epilepsy underwent surgical resection of their epileptogenic focus. Hippocampal and temporal cortical samples were obtained, and subjected to high performance liquid chromatography with electrochemical detection. Levels of 5-hydroxyindoleacetic acid (5-HIAA) in actively spiking temporal cortex were 0.454 +/- 0.012 ng/mg (mean +/- SEM), contrasting with less actively spiking cortex values of 0.248 +/- 0.042 ng/mg and normal literature values, obtained from post-mortem material, of 0.140 +/- 0.050 ng/mg. Similarly, homovanillic acid (NVA) levels were significantly increased in epileptic tissue compared to normal literature values. Actively spiking cortex values were 0.172 +/- 0.001 pg/mg, less active cortex values were 0.058 +/- 0.012 pg/mg, and literature values were 0.011 +/- 0.002 pg/mg. Although a direct statistical comparison between the data reported here and literature values may not be valid, the findings show a continuum from normal through increasingly active electrode sites, likely reflecting a true biologic phenomena. Similarly, statistically significant increases in 5-HIAA and HVA levels were found in hippocampal tissue, which also showed significantly lower dihydroxyphenylacetic ac...Continue Reading

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Citations

Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicolas CostesDidier Le Bars
Sep 14, 2004·Mental Retardation and Developmental Disabilities Research Reviews·Diane C Chugani
Jan 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vladimir V Kalinin
Apr 27, 2016·Current Neurology and Neuroscience Reports·Marian Galovic, Matthias Koepp
Jun 19, 2008·Brain : a Journal of Neurology·Andréy MazaratiRaman Sankar
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D C Chugani, O Muzik
Mar 14, 2007·Current Opinion in Neurology·Aimee F LuatHarry T Chugani
Dec 24, 2005·Epilepsy Currents·Harry T Chugani, Diane C Chugani
Nov 26, 2009·Pediatric Radiology·Sunhee KimAshok Panigrahy
Feb 1, 1996·Synapse·M S Starr
Mar 5, 2003·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·J C Van Der HeydenR A Wevers
Oct 4, 2011·Neurobiology of Disease·Luisa RochaAnna Borsodi

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