A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives

Contact Dermatitis
S T ZaynounW Frain-Bell

Abstract

Using a standardized open photopatch test technique, the phototoxic reactions produced by bergamot oil bergapten (5-methoxypsoralen) the active component of the oil, and xanthotoxin (8-methoxypsoralen) were studied. The reaction was affected by a range of factors such as the vehicle (PMF or ethanol), the concentration of ethanol in the vehicle, the skin site, the interval between application of the psoralen and irradiation, the hydration of the skin, and the degree of natural or sun-induced pigmentation. Repeated photopatch testing at the same skin site produced an increase in sensitivity. Eye colour, natural susceptibility to suntanning, age, and sex, had no effect on the phototoxic response to psoralens.

References

Apr 1, 1976·Contact Dermatitis·R SuhonenV Pirilä
Apr 1, 1975·The Journal of Investigative Dermatology·D W OwensD Troll
Mar 6, 1976·The Medical Journal of Australia
Apr 1, 1973·Archives of Dermatology·A M Kligman, F P Goldstein
Oct 1, 1973·Archives of Dermatology·R L OlsonM A Everett
Sep 1, 1970·Archives of Dermatology·A N Cattano
Apr 1, 1965·Archives of Dermatology·K H Burdick
Jun 1, 1961·The British Journal of Dermatology·K D CROWA D PORTER
Jan 1, 1965·The Journal of Investigative Dermatology·L C HARBER, R L BAER

Citations

Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W W Lovell, D J Sanders
Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·P MorlièreL Dubertret
Mar 1, 1979·Clinical and Experimental Dermatology·W Frain-Bell
Sep 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E GorgusDieter Schrenk
Jul 1, 1984·Contact Dermatitis·S T ZaynounA K Kurban
May 19, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Vera Mahler
Mar 1, 1981·Contact Dermatitis·S T ZaynounA K Kurban

Related Concepts

Teens
Dose-Response Relationship, Drug
Ultramop
Patch Tests
Actinic Reticuloid
Radiation Recall Dermatitis
Skin Pigmentation
Pharmaceutical Vehicles

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Archives of Dermatological Research
M NaganumaT Someya
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A LapczynskiA M Api
Facial Plastic Surgery Clinics of North America
Siegrid S YuRoy C Grekin
© 2021 Meta ULC. All rights reserved