A study of oxidative stress in paucibacillary and multibacillary leprosy

Indian Journal of Dermatology, Venereology and Leprology
P JyothiM P Binitha

Abstract

The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum. The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.

Citations

Mar 19, 2016·PeerJ·Yvelise T Morato-ConceicaoCor J F Fontes
Nov 26, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·H Z Abdel-HafezA A Abd-Elghany
Apr 6, 2019·Frontiers in Immunology·Veronica SchmitzEuzenir Nunes Sarno
Sep 26, 2020·Future Microbiology·Robertha Mr LemesCristiana S de Macedo
Sep 8, 2019·Microbial Pathogenesis·Ved Prakash DwivediDebprasad Chattopadhyay
Jul 22, 2021·Pharmacogenomics and Personalized Medicine·Si-Yu LongHong-Sheng Wang
May 1, 2018·American Journal of Human Genetics·Dong WangYong-Gang Yao

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