PMID: 8952823Oct 1, 1996Paper

A study of platelet activation following coronary angioplasty. Effect on acute occlusion and restenosis

Archives des maladies du coeur et des vaisseaux
C Durrieu-JaïsA T Nurden

Abstract

The development of monoclonal anti-platelet antibodies to activation-dependent epitopes has made possible the study of the appearance of activated platelets in the blood by cytometry. This was undertaken in 35 patients undergoing coronary angioplasty. Blood was sampled through the femoral venous catheter introducer before the procedure, at 3 minutes and 3, 24 and 48 hours after angioplasty. Systematic coronary angiography was performed at about 6 months and vessel diameters were quantified by a digitised technique. In general, platelet activation was not observed before angioplasty or in the first hours following the procedure. On the other hand, a significant number of activated platelets was observed secondarily : 7 +/- 7.3% at the 24th hour and 6.8 +/- 5.9% at the 48th hour. There was a significant correlation between the level of platelet activation before angioplasty and that at the 24th hour (r = 0.52, p = 0.01). There was a tendency to more activated circulating platelets before and 24 hours after angioplasty in patients with acute occlusion. The correlation coefficient between the level of activated platelets 24 hours after angioplasty and progression of stenosis at 6 months was not statistically significant (r = 0.29)....Continue Reading

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