A study of presbycardia, with gender differences favoring ageing women

International Journal of Cardiology
David F GoldspinkN Timothy Cable

Abstract

The impact of ageing on the human cardiovascular system has been the subject of several studies in recent years, but with insufficient emphasis on defining sex-specific differences. To rectify this, gender-specific differences in structure and function in the human cardiovascular system were studied in a European population during natural ageing. Cardiac power output (CPO) was measured and integrated with changes in left ventricular (LV) mass, diastolic, systolic and limb blood flow, blood pressure and exercise capacity in 93 health-screened men and 122 women, aged 20 to 75 years. Correlating with a 21% loss of LV mass, maximum cardiac pumping (i.e. CPOmax=QmaxxMAPmax) and reserve (CR=CPOmax-CPOrest) capacities decreased 20-25% with age in male hearts. In contrast, CPOmax, CR and LV mass were all preserved in ageing women. Maximum cardiac output (Qmax; 26-32%), peak forearm blood flow (FBFpeak; 61%) and exercise capacity (40-50%) all decreased, but more so in men than women. In contrast, systemic vascular resistance (68-75%) and mean arterial pressure (MAPmax; 14-26%) increased in both sexes. CPOrest decreased 27% in men, but was unchanged in women, despite lower early:late diastolic filling (48-51%), Qrest (19-23%) and FBFrest...Continue Reading

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Citations

May 19, 2010·European Journal of Applied Physiology·Beth A ParkerDavid N Proctor
Dec 15, 2010·European Journal of Applied Physiology·Beth ParkerPaul Thompson
Nov 22, 2015·Mechanisms of Ageing and Development·David HoughtonDjordje G Jakovljevic
Apr 2, 2015·International Journal of Cardiology·S S HothiL B Tan
Apr 8, 2015·International Journal of Cardiology·D K H TanL B Tan
May 24, 2015·International Journal of Cardiology·S S HothiL B Tan
Aug 4, 2012·Clinical Physiology and Functional Imaging·Djordje G JakovljevicDavid A Brodie
Jun 4, 2013·International Journal of Cardiology·Muzahir H TayebjeeLip-Bun Tan
May 20, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shanmugakumar ChinnappaAndrew Mooney
May 27, 2017·Experimental Gerontology·Djordje G Jakovljevic
Jan 1, 2015·Circulation. Cardiovascular Imaging·Djordje G JakovljevicMichael I Trenell
Mar 1, 2012·Stroke; a Journal of Cerebral Circulation·Djordje G JakovljevicMichael I Trenell
Oct 14, 2011·Current Opinion in Cardiology·Dawn C Scantlebury, Barry A Borlaug
Dec 20, 2018·Brain Plasticity·Cindy K Barha, Teresa Liu-Ambrose
Sep 20, 2011·International Journal of Cardiology·Shanmugakumar ChinnappaLip-Bun Tan

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