A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.

Cancer Prevention Research
Todd L EdwardsWei Zheng

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related death and usually arises from colorectal polyps. Screening and removal of polyps reduce mortality from CRC. Colorectal polyps are known to aggregate in families; however the genetic determinants for risk of polyps are unknown. In addition, it has been shown that nonsteroidal anti-inflammatory drug (NSAID) use decreases the risk of CRC and the incidence and size of polyps. In this study, we used data from the Tennessee Colorectal Polyp Study and the Tennessee-Indiana Adenoma Recurrence Study to evaluate selected genes from the prostaglandin (PG) metabolism and signaling pathways for association with risk of polyps and for interactions with NSAIDs. Our design consisted of discovery and replication phases for a total of 2,551 Caucasian polyp cases and 3,285 Caucasian controls. We carried out multivariable logistic regression to test for association in both the discovery and replication phase and further examined the results with meta-analysis. We detected association signals in the genes PGE receptor 3 (PTGER3) and 15-hydroxyprostaglandin dehydrogenase (HPGD), both strong biologic candidates for influence on polyp risk. We did not observe the previously reported...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Feb 1, 1997·Human Genetics·F PichaudM F Rousseau-Merck
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Jul 4, 2001·The Journal of Clinical Investigation·C PatronoL A García Rodríguez
Mar 20, 2002·Nature Reviews. Cancer·R A Gupta, R N Dubois
Mar 7, 2003·The New England Journal of Medicine·Robert S SandlerRichard Schilsky
Mar 7, 2003·The New England Journal of Medicine·John A BaronRosalind U van Stolk
Nov 16, 2004·The Journal of Biological Chemistry·Michael G BacklundRaymond N DuBois
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bhagavathi A NarayananBandaru S Reddy
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Min YanSanford D Markowitz
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cornelia M UlrichJeannette Bigler
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanne R Brown, Raymond N DuBois
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mairi MacarthurEmad M El-Omar
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Leah B SansburyElaine Lanza
Sep 1, 2006·The New England Journal of Medicine·Monica M BertagnolliUNKNOWN APC Study Investigators
Sep 1, 2006·The New England Journal of Medicine·Nadir ArberUNKNOWN PreSAP Trial Investigators
Nov 8, 2006·Gastroenterology·John A BaronUNKNOWN APPROVe Trial Investigators
Mar 7, 2007·Annals of Internal Medicine·Catherine DubéUNKNOWN U.S. Preventive Services Task Force
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
Dec 6, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F GaoZ Mo
Feb 12, 2009·International Journal of Colorectal Disease·Zhihong GongJames R Hebert
Feb 13, 2009·Journal of the National Cancer Institute·Bernard F ColeJohn A Baron
Mar 26, 2009·Biochemical and Biophysical Research Communications·Yasuhumi OgawaMasataka Majima
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Min YanSanford D Markowitz
Jun 24, 2009·Oncology Research·Wilbert H M PetersFokko M Nagengast
Jun 25, 2009·Advances in Anatomic Pathology·Efsevia Vakiani, Rhonda K Yantiss
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth L BarryJohn A Baron
Jan 21, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth M PooleCornelia M Ulrich
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yoshifumi BabaShuji Ogino
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 16, 2011·Human Genetics·Ulrike PetersGraham Casey

❮ Previous
Next ❯

Citations

Jan 17, 2014·Journal of Gastroenterology·Hsin-En HuangChih-Jen Chang
Dec 26, 2012·Gastroenterology·Ulrike PetersUNKNOWN Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium
Jun 30, 2018·International Journal of Molecular Medicine·Xiaoting Sun, Qi Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.