A Study of Red Cell Distribution Width in Neonatal Sepsis.

Pediatric Emergency Care
Dalia Monir EllahonyMarwa M Farag

Abstract

The objective of this study was to evaluate a new nontraditional value of the red cell distribution width (RDW) in predicting the clinical outcome of neonatal sepsis. In this retrospective study, data were collected from the medical files of 500 full-term neonates with a diagnosis of early onset or late onset sepsis. Baseline RDW and other traditional biomarkers, including C-reactive protein (CRP), total leucocytic count, and platelet count were analyzed in light of the clinical data. The primary outcome was 30-day mortality. Red cell distribution width was significantly higher in nonsurvivors compared with survivors (P < 0.0001). Red cell distribution width was significantly elevated in infants with septic shock compared with those having severe sepsis and those with sepsis (P < 0.0001). A strong positive correlation was found between RDW and CRP (r = 0.8; P <0.0001). Red cell distribution width had an area under the receiver operating characteristic curve of 0.75 for prediction of mortality, which was almost equal to that of CRP and platelet count. Furthermore, logistic regression analysis showed a positive association of RDW with mortality (odds ratio, 1.31; 95% confidence interval, 1.241-1.399). Red cell distribution width ...Continue Reading

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Citations

Sep 19, 2019·World Journal of Gastroenterology : WJG·Fang-Xiao ZhangXiao-Chun Ma
Dec 28, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Pelin Dogan, Ipek Guney Varal
Apr 8, 2021·The Journal of International Medical Research·Yide LiLiang Luo
Aug 3, 2021·Computational and Mathematical Methods in Medicine·Ming DaiLei Cao

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