PMID: 856939Apr 1, 1977Paper

A study of releasable Ca fractions in smooth muscle cells of the rabbit aorta

The Journal of General Physiology
R Deth, R Casteels


The distribution of Ca in the cellular compartment of smooth muscle cells of the rabbit aorta has been studied by analyzing the effect of norepinephrine, caffeine, and DNP on 45Ca exchange and on the pattern of tension development. These three substances increase the release of 45Ca from the tissue, but DNP acts more slowly than norepinephrine or caffeine. Also, the effect of norepinephrine and caffeine on tension development occurs almost immediately, while that of DNP appears only after a delay of 5 min. Study of the effect of these substances on the Ca efflux has shown that norepinephrine and caffeine act probably on the same Ca compartment, while DNP seems to act on a different compartment with a slower exchange rate. The difference between these two pools could be further demonstrated by studying Ca release after loading the tissues with tracer in either K-rich solution or in a solution with reduced [Ca]o. The K depolarization results in an excessive loading of the cells with 45Ca. Exposing these cells during the efflux procedure to a solution containing DNP causes a much larger release of 45Ca than that observed after a loading procedure in normal solution. In contrast, the release of 45Ca elicited in such tissues by nore...Continue Reading


Jan 28, 1977·The Journal of Membrane Biology·R Deth, C van Breemen
Sep 9, 1975·Pflügers Archiv : European journal of physiology·C van BreemenG Ferrari
Aug 1, 1975·The Anatomical Record·G DebbasL Hurwitz
Mar 15, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C E DevineA V Somlyo
Oct 1, 1969·Archives internationales de physiologie et de biochimie·C van Breemen
Jun 1, 1974·Journal of Molecular and Cellular Cardiology·M L Hess, G D Ford
Sep 12, 1973·Nature: New Biology·M A DevynckP Fromageot
Apr 4, 1974·Pflügers Archiv : European journal of physiology·R Deth, C van Breemen
Jan 26, 1973·Science·L HurwitzE J Landon
Apr 1, 1972·The Japanese Journal of Physiology·T Sakai, T Iizuka
Jan 1, 1973·Circulation Research·O S SteinslandS M Kirpekar
Apr 22, 1974·Pflügers Archiv : European journal of physiology·C van Breemen, R Casteels
Apr 21, 1972·Science·D F FitzpatrickL Hurwitz
Apr 1, 1971·The Journal of General Physiology·Y Ito, H Kuriyama
Oct 28, 1958·Acta Physiologica Scandinavica·J AXELSSON, S THESLEFF


Jul 1, 1979·Pflügers Archiv : European journal of physiology·K E Kamm, R Casteels
Aug 15, 1985·Experientia·A V SomlyoA P Somlyo
Jul 15, 1985·Experientia·G DroogmansR Casteels
Jan 1, 1983·Annals of Biomedical Engineering·A P SomlyoD Kowarski
Apr 24, 1981·European Journal of Pharmacology·R C Deth, C J Lynch
Jun 6, 1991·European Journal of Pharmacology·J CortijoE J Morcillo
Oct 29, 1991·European Journal of Pharmacology·W F ChiouC F Chen
May 14, 1992·European Journal of Pharmacology·W F ChiouC F Chen
Jan 1, 1988·Life Sciences·H Karaki, G B Weiss
Jan 1, 1989·Pharmacology & Therapeutics·T M Lincoln
Nov 1, 1992·Pharmacology & Therapeutics·L MissiaenR Casteels
Jan 1, 1994·Pharmacology & Therapeutics·P I Aaronson
May 1, 1982·Journal of the Autonomic Nervous System·C I LinK Y Lin
Jul 1, 1981·Molecular and Cellular Endocrinology·J N Wells, G L Kramer
Nov 1, 1988·Medical Hypotheses·T J Hardy, P B Williams
Apr 10, 1992·European Journal of Pharmacology·D W Hay, R M Wadsworth
Aug 16, 1994·European Journal of Pharmacology·R S Garcha, A D Hughes
Sep 23, 1997·British Journal of Pharmacology·R S Garcha, A D Hughes
Mar 1, 1986·The Journal of General Physiology·H Yamamoto, C van Breemen
Nov 27, 2002·Journal of Cardiovascular Pharmacology·Cristina RubioElisabet Vila
Feb 1, 1987·Clinical and Experimental Pharmacology & Physiology·C A HamiltonJ L Reid
Aug 1, 1996·British Journal of Pharmacology·M PlamiG Sgaragli
Apr 28, 1978·Annals of the New York Academy of Sciences·A P SomlyoA Scarpa
Jan 1, 1986·Annals of the New York Academy of Sciences·A P SomlyoA V Somlyo
Dec 1, 1981·Pflügers Archiv : European journal of physiology·R CasteelsJ Van Eldere
Sep 1, 1989·Toxicology and Applied Pharmacology·G D HokeW D Matthews
Nov 1, 1982·Progress in Cardiovascular Diseases·M A Movsesian
Jan 1, 1988·Annals of the New York Academy of Sciences·C van BreemenC Twort
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·S ManziniA Meli
Sep 1, 1983·Journal of Autonomic Pharmacology·J BouR Massingham
Jan 1, 1992·Pediatric Pulmonology·E N KeklikianT H Shaffer
Apr 1, 1984·Acta Pharmacologica Et Toxicologica·E MikkelsenO L Pedersen
May 1, 1978·The American Journal of Physiology·R C Deth
May 1, 1981·The American Journal of Physiology·R C Deth, C J Lynch
Jan 1, 1988·The American Journal of Physiology·C M Hai, R A Murphy
Sep 1, 1988·The American Journal of Physiology·C M Hai, R A Murphy

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