PMID: 9530992Apr 8, 1998Paper

A study of the anti-pyretic effect of quinine, an alkaloid effective against cerebral malaria, on fever induced by bacterial endotoxin and yeast in rats

The Journal of Pharmacy and Pharmacology
F A Santos, V S Rao

Abstract

The effect of quinine on fever induced by lipopolysaccharide and brewer's yeast has been investigated in rats. Oral administration of 50 or 100 mg kg(-1) quinine, doses which had no effect on normothermic rats, significantly reduced lipopolysaccharide- (50 microg kg(-1), i.m.) and yeast- (2 g kg(-1)) induced fever in rats. Pentoxifylline (100 mg kg(-1)), a tumour necrosis factor antagonist also attenuated the febrile response induced by lipopolysaccharide, but not that by yeast, in a manner similar to quinine. Piroxicam (5 mg kg(-1)), a cyclooxygenase inhibitor suppressed both types of fever with a longer duration of action. In addition to its anti-pyretic effect, quinine had a significant anti-inflammatory effect in the carrageenan model of acute inflammation in the hind-paw of rats. The results indicate the anti-inflammatory and anti-pyretic potential of quinine which might be important in addition to its anti-plasmodial action in the therapy of cerebral malaria.

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Citations

Apr 12, 2001·Journal of Ethnopharmacology·G J AmabeokuE Springfield
Jan 23, 2014·Environmental Toxicology and Pharmacology·Karunakaran VijayakaranSouvendra Nath Sarkar
Aug 2, 2005·Journal of Neuroscience Methods·Jorgete TomazettiCarlos Fernando Mello
Aug 24, 2013·Journal of Parasitology Research·J N BoampongE Woode
Jan 13, 2012·Environmental Toxicology and Pharmacology·Wasif AhmadSouvendra Nath Sarkar
Sep 12, 2006·Bioorganic & Medicinal Chemistry·Mange Ram YadavR Balaraman
Jun 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Bagher MajnooniJavier Echeverría

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