A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Cuijuan ShiQi Xu

Abstract

Major depressive disorder (MDD) is a common chronic mental disease with diverse clinical presentation. Although the genome-wide association study (GWAS) has remarkably facilitated the understanding of genetic mechanisms of MDD at a deep molecular level, the combined effect of these disease-underlying genes still needs further investigation. A total of 1,062 unrelated patients with MDD and 992 unrelated healthy subjects were recruited from a Chinese Han population to test 16 MDD-associated genes identified by GWAS. A tag SNP-based linkage-disequilibrium map was then constructed over the loci that showed MDD association in the study sample. Of the 16 genes tested, EHD3 and FREM3 were associated with MDD in the Chinese population. The conditional test showed disease association for the rs619002(EHD3)-rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)-rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)-rs1112714(T) combination (OR = 0, P = 4.02 × 10(-6) ) and for the rs644926(A)-rs11938298(G) combination (OR = 0.12, 95% CI = 0.035-0.39, P = 3.85 × 10(-6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia ...Continue Reading

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Apr 29, 2015·Current Biology : CB·Na CaiJonathan Flint
Dec 24, 2017·Proteomics. Clinical Applications·Liming ShenJian Zhai
Apr 25, 2014·Circulation Research·Jerry CurranPeter J Mohler
Mar 7, 2020·American Journal of Medical Genetics. Part a·Amanda Barone PritchardDavid E Clouthier

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