A study of the effectiveness of bilateral transcranial magnetic stimulation in the treatment of the negative symptoms of schizophrenia

Brain Stimulation
Paul B FitzgeraldZafiris J Daskalakis

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is increasingly being investigated as a potential treatment for a number of psychiatric disorders, including schizophrenia. Previous rTMS studies have targeted the left-side prefrontal cortex (PFC) in the treatment of negative symptoms, with inconsistent findings. Some imaging evidence suggests right-sided or bilateral PFC involvement in negative symptoms, areas yet to be investigated for rTMS treatment. The study therefore aimed to assess the efficacy of bilateral high-frequency rTMS in the treatment of negative symptoms. A 2-arm double-blind randomized controlled trial was conducted with 20 patients with a diagnosis of schizophrenia or schizoaffective disorder, and moderate-to-severe treatment-resistant negative symptoms. Participants received a 3-week course of high-frequency bilateral rTMS or sham. Twenty trains (5 seconds duration) of 10 Hz rTMS at 110% of the RMT were administered to each PFC daily, 5 days a week. No significant group or time differences in the Scale for the Assessment of Negative Symptoms (SANS) scores or cognitive outcomes were evident. However, a trend for greater reduction in scores on the autistic preoccupation scale of the Positive and Negative Sym...Continue Reading

References

Dec 1, 1992·Archives of General Psychiatry·A WolkinJ Rotrosen
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Aug 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·E CohenF J Lomeña
Nov 18, 2000·Biological Psychiatry·M S GeorgeJ C Ballenger
Apr 16, 2003·Schizophrenia Bulletin·Jitschak G StorosumAndré W Broekmans
Jul 29, 2004·Schizophrenia Bulletin·Matti M HoliHannu Naukkarinen
Sep 18, 2004·Schizophrenia Research·Paul B FitzgeraldJ Kulkarni
Mar 9, 2005·Archives of General Psychiatry·Rajendra A MoreyAysenil Belger

❮ Previous
Next ❯

Citations

Oct 15, 2008·Current Opinion in Psychiatry·Juan J López-IborJosé I Pastrana
Nov 3, 2011·The Australian and New Zealand Journal of Psychiatry·Paul B Fitzgerald
Dec 14, 2011·Neurophysiologie clinique = Clinical neurophysiology·J-P LefaucheurL Garcia-Larrea
Oct 15, 2013·Expert Review of Neurotherapeutics·Daphne Voineskos, Zafiris J Daskalakis
Jul 19, 2015·Schizophrenia Research·Jozarni J Dlabac-de LangeAndré Aleman
Jul 4, 2012·Neuropharmacology·Asli Demirtas-TatlidedeAlvaro Pascual-Leone
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Sep 17, 2013·Neuroscience and Biobehavioral Reviews·Gagan FervahaGary Remington
Apr 29, 2011·The International Journal of Neuropsychopharmacology·Yechiel LevkovitzAbraham Zangen
Jun 21, 2016·Expert Review of Clinical Pharmacology·Shyam Sundar ArumughamChittaranjan Andrade
Feb 11, 2014·Brain Stimulation·Hema NawaniGanesan Venkatasubramanian
Jun 24, 2008·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Paul Fitzgerald
May 1, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Philip M LewisPaul B Fitzgerald
Aug 21, 2015·The Cochrane Database of Systematic Reviews·Nadine DougallAndrew McIntosh
Sep 19, 2015·Open Biology·Evgeny A ErmakovGeorgy A Nevinsky
Jan 28, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sri Mahavir AgarwalGanesan Venkatasubramanian
Sep 25, 2017·Frontiers in Human Neuroscience·Wei LiuBing Jin Li
Feb 28, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Tarek K RajjiPaul B Fitzgerald
Feb 8, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Nigel I KennedySophia Frangou
Sep 1, 2015·Current Treatment Options in Psychiatry·Mehmet E Dokucu
May 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M M PopovV G Kaleda
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Stephanie HomanPhilipp Homan
Apr 13, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen J BrandtMichael M Francis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here