PMID: 8969397Dec 1, 1996Paper

A study of the effects of extracorporeal circulation on the immunologic system of humans

Journal of Cardiothoracic and Vascular Anesthesia
S SiminelakisE Chlapoutakis

Abstract

The objectives of this study were to quantify the immunosuppressive effects of cardiopulmonary bypass (CPB) and to identify mechanisms responsible for the postoperative immunosuppression of patients undergoing cardiac surgery. A prospective study from 20 consecutive patients. The same team operated on all patients in a major teaching hospital, and the immunologic tests were performed in the hospital's hematology laboratory. Twenty patients were studied who had consented to participate in the study. All patients underwent valve replacement under general anesthesia. The changes in the white blood cell count (WBC), in the B, T, T4, T8 lymphocytes, the concentrations of C-reactive protein (CRP), a1-antitrypsin (A1AT), a2-macroglobulin (A2MG), C3, C4 immunoglobulin A (IgA), IgM, IgG, Kappa (K), and lambda (L) chains were studied. The postoperative immune response was expressed with (1) increased mean axillary temperature (37.5 degrees +/- 0.62 degrees) in the first postoperative 24 hours; (2) increase of WBC (p < 0.001) and T8 (p < 0.01); (3) reduction of C3 (p = 0.01) and A2MG (p < 0.01); (4) reduction of IgA (p < 0.001) and IgG, K, L chains (p < 0.01); and (5) reduction of T (p < 0.01) and T4 (p < 0.01). In the first 24 hours post...Continue Reading

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Citations

Jul 12, 2002·Pediatric Pulmonology·Diarmuid R O'Donnell, David Carrington
Mar 27, 2001·Transplantation Proceedings·M ErrenM C Deng
Sep 15, 2000·Japanese Heart Journal·D P CiocaM Isobe
Mar 15, 2005·Clinical and Experimental Immunology·M NoursadeghiJ Cohen

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