Coagulase-negative staphylococci (CNS) are among the most prevalent microorganisms that colonize and cause sepsis in neonatal intensive care units (NICU). We had previously identified a strain of CNS, Staphylococcus haemolyticus (TOR-35), in the NICU at Mount Sinai Hospital, that had been repeatedly isolated from blood cultures from neonates. We therefore carried out a prospective study to determine the frequency and time of colonization and the frequency of bacteremia in neonates over a 3.5 month period. This was accomplished by obtaining surface swabs within 1 h of birth and on days 3, 5, and 7 and by characterizing all blood culture isolates of CNS. We also determined what percentage of neonatal CNS bacteremias were due to this strain, between January 1, 1987 and December 31, 1990, by retrieving and typing all stock cultures of CNS from that period. All isolates were typed by species identification and antimicrobial susceptibility profile code. There were 76 (38%) neonates that became colonized with the TOR-35 strain at some time during their NICU stay. Lower birth weight was associated with colonization (p < 0.001), as was lower gestational age (p < 0.001). Only 1 neonate had a positive blood culture isolate for the TOR-35 ...Continue Reading
Isolation and characterization of a macrophage-derived high molecular weight protein involved in the regulation of mucus-like glycoconjugate secretion
Comparison of blood cultures with corresponding venipuncture site cultures of specimens from hospitalized premature neonates
Evaluation of restriction endonuclease fingerprinting of chromosomal DNA and plasmid profile analysis for characterization of multiresistant coagulase-negative staphylococci in bacteremic neonates.
Evaluation of coagulase-negative staphylococcal isolates from serial nasopharyngeal cultures of premature infants
Extra hospital stay and antibiotic usage with nosocomial coagulase-negative staphylococcal bacteremia in two neonatal intensive care unit populations.
Evaluation of five commercial systems for identification of coagulase-negative staphylococci to species level
The evaluation of a typing scheme for coagulase-negative staphylococci suitable for epidemiological studies
Microbiologic studies of coagulase-negative staphylococci isolated from patients with nosocomial bacteraemias
Plasmid DNA analysis of Staphylococcus epidermidis isolated from blood and colonization cultures in very low birth weight neonates.
Fifteen-year experience with bloodstream isolates of coagulase-negative staphylococci in neonatal intensive care.
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Antimicrobic susceptibility and plasmid profile analysis as identity tests for multiple blood isolates of coagulase-negative staphylococci.
Phenotypic and genotypic characterisation of blood isolates of coagulase-negative staphylococci in the newborn
Genetic population structure of coagulase-negative staphylococci associated with carriage and disease in preterm infants
Staphylococcus haemolyticus disseminated among neonates with bacteremia in a neonatal intensive care unit in Rio de Janeiro, Brazil
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CRISPR & Staphylococcus
CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.