PMID: 2487061Apr 1, 1989Paper

A study of the local toxicity of agents used for variceal injection sclerotherapy

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
C S RobertsonD L Morris

Abstract

Injection sclerotherapy is widely used in the treatment of oesophageal varices. However, few studies have compared the local toxicity of sclerosant agents which may be important if serious local complications are to be avoided. In this study the depth of injury caused by submucosal injection of increasing concentrations of sodium tetradecyl sulphate, polidocanol, 5% ethanolamine oleate and 5% varicosid in rabbits stomach, has been compared by histopathological examination. Macroscopic ulceration was seen in 14.6% of injection sites. Increasing concentrations of sodium tetradecyl sulphate and polidocanol produced increasingly extensive microscopic inflammation. Five percent varicosid caused more inflammation than 5% ethanolamine and only 3% polidocanol and 5% varicosid caused full thickness inflammation. Only 5% ethanolamine produced inflammation consistently confined to the mucosa and submucosa. On the basis of this study we feel that 5% ethanolamine is the most suitable agent for injection sclerotherapy.

Citations

Mar 1, 1996·Digestive Diseases and Sciences·M TatemichiH Ishii
Oct 27, 2004·Archives of Toxicology·Christian Grosse-SiestrupDavid A Groneberg
Nov 23, 2013·Oral and Maxillofacial Surgery·Walessa Brasil da SilvaSérgio de Melo Alves-Junior
Aug 10, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R NiknamR Malekzadeh
Apr 26, 2015·Gastrointestinal Endoscopy·Antonio FacciorussoNicola Muscatiello
Nov 28, 2008·Disability and Rehabilitation·McKay Moore SohlbergPei-Fang Hung
Oct 6, 2011·European Journal of Gastroenterology & Hepatology·Ramin NiknamReza Malekzadeh

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