PMID: 8971670Dec 1, 1996Paper

A study of the pharmacokinetics and tissue residues of an oral trimethoprim/sulphadiazine formulation in healthy pigs

Journal of Veterinary Pharmacology and Therapeutics
S GarwackiM Zaremba

Abstract

Twenty-six healthy female pigs weighing 19.5-33 kg were used in three separate experiments. The animals were fed individually twice a day. Trimethoprim/sulphadiazine (TMP/SDZ) formulation was added to feed in the amount of 6 mg/kg bw (TMP) and 30 mg/kg bw (SDZ). TMP and SDZ concentrations in blood plasma, muscles, liver and kidneys were measured. Pharmacokinetic parameters show that the absorption of TMP from the alimentary tract in pigs is faster than the absorption of SDZ, and the elimination of TMP is slower than that of SDZ. The absorption half-lives were 0.96 (TMP) and 2.24 h (SDZ), whereas elimination half-lives were 5.49 (TMP) and 4.19 h (SDZ). The observed TMP:SDZ ratios in blood plasma after multiple dose administration ranged from 1:11.4 to 1:23.2. One day after administration of the last dose of TMP/SDZ the plasma concentration ratio was 1:15.5, but in muscles, liver and kidneys it was much lower: 1:0.79, 1:0.14 and 1:1.53 respectively. The absolute TMP and SDZ tissue concentrations 1 day after the last multiple dose administration were very low (maximum TMP: 0.29 micrograms/g in liver; maximum SDZ: 0.23 micrograms/g in kidneys). Neither drug was detected in any tissue 8 days after the last administration of TMP/SDZ....Continue Reading

References

Feb 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Nov 1, 1976·Zentralblatt für Veterinärmedizin. Reihe A·A Romváry, M S Horvay
Oct 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Mar 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·C R KilroyG D Koritz
Dec 1, 1984·Journal of Autonomic Pharmacology·R YamamotoK Takasaki
May 1, 1984·Acta Pharmacologica Et Toxicologica·C FriisF Rasmussen
Nov 1, 1984·Acta Pharmacologica Et Toxicologica·N Gyrd-HansenF Rasmussen
Jan 1, 1994·Research in Veterinary Science·P Nielsen, N Gyrd-Hansen

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