A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression.

Neuropathology and Applied Neurobiology
A J ThomasJohn T O'Brien

Abstract

Previous studies investigating the serotonin transporter (SERT) in depression have been inconsistent and included a large proportion of subjects who had committed suicide. In Alzheimer's disease studies have generally reported a reduction in SERT density but have not compared Alzheimer's disease subjects with and without comorbid major depression. We conducted a post mortem study of SERT density in the prefrontal cortex in normal elderly, a group of elderly depressed subjects and in Alzheimer's disease subjects with and without major depression. A post mortem study comparing SERT density in the prefrontal cortex in elderly controls (n = 10), subjects with major depression (n = 8) and subjects with Alzheimer's disease with (n = 9) and without (n = 5) comorbid major depression. We used autoradiography to measure the density of [3H]CN-IMI binding (non-specific binding determined with citalopram) to the SERT in the prefrontal cortex. We found a marked reduction in specific SERT binding in the prefrontal cortex in Alzheimer's disease subjects compared with both control (P = 0.002) and depressed subjects (P = 0.004) but no difference in SERT binding between depressed and control subjects or between Alzheimer's disease subjects with a...Continue Reading

References

May 1, 1991·Psychological Medicine·A BurnsR Levy
Mar 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·E MurphyJ Slattery
Feb 1, 1988·Biological Psychiatry·G S AlexopoulosC A Shamoian
Aug 1, 1987·Annals of Neurology·R J D'AmatoS H Snyder
Feb 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·E K PerryR H Perry
Jun 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J N JoyceJ E Kleinman
Nov 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·R C Baldwin, B Tomenson
May 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E V Gurevich, J N Joyce
May 8, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C C MeltzerC F Reynolds
Jun 17, 1998·Psychological Medicine·R H McAllister-WilliamsA H Young
Aug 8, 1998·International Journal of Geriatric Psychiatry·K RitchieB Ledésert
Jun 6, 2000·Journal of Affective Disorders·C BallardR Perry
Jun 23, 2000·Biological Psychiatry·W Bligh-GloverC A Stockmeier
Mar 20, 2001·Archives of General Psychiatry·B W PenninxW van Tilburg
Jul 10, 2002·Journal of Affective Disorders·Clive BallardClive Holmes
Aug 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Alan J ThomasJohn T O'Brien
Sep 7, 2002·Archives of General Psychiatry·Alan J ThomasRobert H Perry
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David C Purselle, Charles B Nemeroff
Apr 3, 2003·International Psychogeriatrics·Serge GauthierUNKNOWN Donepezil MSAD Study Investigators Group
Mar 17, 2004·Journal of Affective Disorders·Alan J ThomasJohn T O'Brien
Jul 15, 2005·History of Psychiatry·Jatinder Bains

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Citations

Dec 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kjell NågrenJuha O Rinne
Feb 21, 2008·Zeitschrift für Gerontologie und Geriatrie·S Schaller
Aug 19, 2014·BioMed Research International·Xiao-Ling LiLan Tan
Jul 7, 2012·Progress in Neurobiology·José Julio RodríguezAlexei Verkhratsky
Sep 29, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Rita BellaGiovanni Pennisi
Jan 8, 2014·Journal of Geriatric Psychiatry and Neurology·Kentaro Hirao, Gwenn S Smith
Sep 16, 2017·Brain Imaging and Behavior·Xixi WangUNKNOWN and the Alzheimer’s Disease Neuroimaging Initiative
Jan 1, 2015·Alzheimer's Research & Therapy·Milap A NowrangiPaul B Rosenberg
Dec 13, 2019·Journal of the International Neuropsychological Society : JINS·Joanna CiafonePeter Gallagher
May 17, 2017·Journal of Alzheimer's Disease : JAD·Vasiliki OrgetaRobert Howard
Apr 5, 2019·Neuroscience Letters·Saikat ChakrabortyHongxin Dong
Jul 21, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yasuomi OuchiKazuhiko Nakamura

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