PMID: 9539315Apr 16, 1998Paper

A study of the viral etiology of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease)

Journal of Korean Medical Science
J HuhG Gong

Abstract

Histiocytic necrotizing lymphadenitis (HNL) or Kikuchi's disease is a distinctive, self-limited disorder characterized by necrotizing cervical lymphadenopathy in young individuals. HNL is more prevalent among Asians and is a relatively common disorder among Koreans. A preceding fever, lymphopenia, and occasional skin rashes suggest a viral etiology and there have been sporadic reports of viral association. However, so far, no infectious agent has been proven to be etiologically related. In the present study, the authors examined HNL tissue samples for the presence of the genome of herpesviridae. A polymerase chain reaction was performed on 12 freshly frozen lymph nodes with HNL with a single pair of consensus primers selected within a highly conserved region of the DNA polymerase gene of the Epstein-Barr virus (EBV), designed to detect herpes simplex type 1 (HSV1), herpes simplex virus type 2 (HSV2), and cytomegalovirus (CMV) in addition to EBV. The amplified products of known sizes were then analyzed by a single restriction enzyme treatment for confirmation. No viral DNA was amplified in any of the 12 cases of histiocytic necrotizing lymphadenitis. The authors conclude that there is no evidence that HSV1, HSV2, CMV, or EBV pla...Continue Reading

Citations

Sep 10, 2014·International Journal of Pediatric Otorhinolaryngology·Yosep Chong, Chang Suk Kang
Nov 20, 2012·Rheumatology International·Jorge LabradorRamon García-Sanz
Nov 6, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yun-Ju ChoiKi-Hyun Cho
Jul 27, 2004·American Journal of Clinical Pathology·Xavier BoschElias Campo
Jul 6, 2007·La Presse médicale·Jean-François ViallardJean-Luc Pellegrin
Jun 30, 2000·American Journal of Clinical Pathology·S D Hudnall
Sep 7, 2012·Case Reports in Otolaryngology·Vikrant VeerWolfgang Issing
Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A KomócsiL Czirják
Feb 24, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Sondes MseddiTaoufik Souissi
Oct 13, 2007·Viral Immunology·Wei-Ping ZhangGao-Sheng Huang
Nov 26, 2008·Revista médica de Chile·José Manuel López M
Feb 8, 2019·Journal of Veterinary Research·Ana OliveiraPatrícia Poeta
Feb 13, 2009·Renal Failure·Lazaros GionanlisKostas Sombolos
Sep 26, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Youzhou TangFuyou Liu
Feb 12, 2002·The Journal of Dermatology·Sambit K MohantyMahamaya Saha
Apr 6, 2021·Molecular and Cellular Probes·Songtham AnuntakarunOnrapak Reamtong
Apr 12, 2007·Archives of Pathology & Laboratory Medicine·Min-Sun ChoWoo Ick Yang

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