A study of whether automated Diabetic Retinopathy Image Assessment could replace manual grading steps in the English National Screening Programme

Journal of Medical Screening
Venediktos V KapetanakisAdnan Tufail

Abstract

Diabetic retinopathy screening in England involves labour intensive manual grading of digital retinal images. We present the plan for an observational retrospective study of whether automated systems could replace one or more steps of human grading. Patients aged 12 or older who attended the Diabetes Eye Screening programme, Homerton University Hospital (London) between 1 June 2012 and 4 November 2013 had macular and disc-centred retinal images taken. All screening episodes were manually graded and will additionally be graded by three automated systems. Each system will process all screening episodes, and screening performance (sensitivity, false positive rate, likelihood ratios) and diagnostic accuracy (95% confidence intervals of screening performance measures) will be quantified. A sub-set of gradings will be validated by an approved Reading Centre. Additional analyses will explore the effect of altering thresholds for disease detection within each automated system on screening performance. 2,782/20,258 diabetes patients were referred to ophthalmologists for further examination. Prevalence of maculopathy (M1), pre-proliferative retinopathy (R2), and proliferative retinopathy (R3) were 7.9%, 3.1% and 1.2%, respectively; 4749 ...Continue Reading

References

Aug 8, 2009·The British Journal of Ophthalmology·Alan D FlemingUNKNOWN Scottish Diabetic Retinopathy Clinical Research Network
Oct 14, 2009·IEEE Transactions on Medical Imaging·Meindert NiemeijerMichael D Abramoff
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Dec 8, 2009·The British Journal of Ophthalmology·G S ScotlandUNKNOWN Scottish Diabetic Retinopathy Clinical Research Network
Apr 20, 2010·Ophthalmology·Michael D AbràmoffGwénolé Quellec
Sep 23, 2010·The British Journal of Ophthalmology·Alan D FlemingJohn A Olson
Mar 16, 2013·JAMA Ophthalmology·Michael D AbràmoffMeindert Niemeijer

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Citations

Aug 9, 2016·The Lancet. Diabetes & Endocrinology·Gavin S TanTien Yin Wong
Apr 24, 2017·Vision Research·Bianca S GerendasUrsula Schmidt-Erfurth
Dec 21, 2017·Scientific Reports·Christian LeibigSiegfried Wahl
Apr 28, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Igor KozakMoritz Winkler
Aug 2, 2019·Current Diabetes Reports·Valentina BellemoDaniel Shu Wei Ting
Aug 21, 2020·Translational Vision Science & Technology·Yuchen XieDaniel S W Ting

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Software Mentioned

iGrading
Retmarker
Digital Health Care system
Medalytix
EyeArt
ENSCDR

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