Abstract
Diabetic retinopathy screening in England involves labour intensive manual grading of digital retinal images. We present the plan for an observational retrospective study of whether automated systems could replace one or more steps of human grading. Patients aged 12 or older who attended the Diabetes Eye Screening programme, Homerton University Hospital (London) between 1 June 2012 and 4 November 2013 had macular and disc-centred retinal images taken. All screening episodes were manually graded and will additionally be graded by three automated systems. Each system will process all screening episodes, and screening performance (sensitivity, false positive rate, likelihood ratios) and diagnostic accuracy (95% confidence intervals of screening performance measures) will be quantified. A sub-set of gradings will be validated by an approved Reading Centre. Additional analyses will explore the effect of altering thresholds for disease detection within each automated system on screening performance. 2,782/20,258 diabetes patients were referred to ophthalmologists for further examination. Prevalence of maculopathy (M1), pre-proliferative retinopathy (R2), and proliferative retinopathy (R3) were 7.9%, 3.1% and 1.2%, respectively; 4749 ...Continue Reading
References
May 17, 2007·The British Journal of Ophthalmology·S PhilipJ A Olson
Jun 23, 2007·The British Journal of Ophthalmology·G S ScotlandJ A Olson
Nov 21, 2007·Diabetes Care·Michael D AbràmoffBram van Ginneken
Aug 8, 2009·The British Journal of Ophthalmology·Alan D FlemingUNKNOWN Scottish Diabetic Retinopathy Clinical Research Network
Oct 14, 2009·IEEE Transactions on Medical Imaging·Meindert NiemeijerMichael D Abramoff
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Dec 8, 2009·The British Journal of Ophthalmology·G S ScotlandUNKNOWN Scottish Diabetic Retinopathy Clinical Research Network
Apr 20, 2010·Ophthalmology·Michael D AbràmoffGwénolé Quellec
Sep 23, 2010·The British Journal of Ophthalmology·Alan D FlemingJohn A Olson
May 17, 2011·PloS One·Sarah MackenzieCatherine Egan
Dec 17, 2011·PloS One·Keith GoatmanStephen Nussey
Apr 28, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·N HexD Varley
Nov 15, 2012·Diabetes Care·Irene M StrattonPeter H Scanlon
Mar 16, 2013·JAMA Ophthalmology·Michael D AbràmoffMeindert Niemeijer
Feb 15, 2014·BMJ Open·Gerald LiewCatey Bunce
Citations
Aug 9, 2016·The Lancet. Diabetes & Endocrinology·Gavin S TanTien Yin Wong
Dec 17, 2016·Health Technology Assessment : HTA·Adnan TufailAlicja R Rudnicka
Apr 24, 2017·Vision Research·Bianca S GerendasUrsula Schmidt-Erfurth
Dec 21, 2017·Scientific Reports·Christian LeibigSiegfried Wahl
Dec 28, 2017·PloS One·Pritam BawankarSuneet Sood
Mar 10, 2018·Eye·Ramachandran RajalakshmiViswanathan Mohan
May 8, 2020·The British Journal of Ophthalmology·Abraham Olvera-BarriosJohn Anderson
Apr 28, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Igor KozakMoritz Winkler
Jun 7, 2019·Diabetes Technology & Therapeutics·Rajendra PradeepaViswanathan Mohan
Apr 22, 2020·Eye and Vision·Gilbert LimDaniel S W Ting
Aug 2, 2019·Current Diabetes Reports·Valentina BellemoDaniel Shu Wei Ting
Aug 21, 2020·Translational Vision Science & Technology·Yuchen XieDaniel S W Ting
Jan 13, 2021·Eye·José Tomás Arenas-CavalliRodrigo Donoso