PMID: 8583164Dec 1, 1995Paper

A study on effect of mechanical irritation in development and progression of tongue cancer

Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan
T Sato

Abstract

It is considered that the mechanical irritation acts as an inducer in the canceration process of tongue cancer. The purpose of this study was to clarify the effect of mechanical irritation on the development and progression of tongue cancer. Leukoplakia and cancer were produced on the hamster tongue by paratripsis and applying 1% DMBA acetone solution 3 times per week for 8 or 10 weeks, and there after only paratripsis was continued. The effect of mechanical irritation was examined histopathologically. The intensity of DNA damage caused by mechanical irritation was investigated by measuring the activity of Poly (ADP-ribose) polymerase (PADPRP), which is an enzyme associated with DNA damage. After carcinogenic treatment, canceration of leukoplakia and early carcinoma progressed into become advanced carcinoma histopathologically by mechanical irritation only. In the precancerous condition, active oxygen was found in part of the subepitherial inflammatory cell infiltration and in part of the cancer cells of carcinoma. The activity of PADPRP increased during the scratching period. These results suggest that the mechanical irritation acts accelatively in canceration and progression of tongue cancer and causes DNA damage.

Citations

Dec 2, 2010·Clinical Oral Investigations·Marinka BaričevićMarinka Mravak Stipetić
Aug 30, 2014·Oral Oncology·Sangee ManoharanGuy D Eslick
May 12, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Eduardo David PiemonteMabel Brunotto
May 10, 2017·International Journal of Dentistry·Jerónimo P LazosMabel N Brunotto
Apr 1, 2021·Seminars in Cancer Biology·Saeed H ManjiliMasoud H Manjili

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