PMID: 9546266Apr 18, 1998Paper

A study on epidermal proliferation ability in cholesteatoma

The Laryngoscope
Y TanakaH Moriyama

Abstract

With the objective of estimating proliferation ability of epidermis of middle ear cholesteatoma, the difference in proliferating cell nuclear antigen (PCNA) staining between the skin of the bone region of the external ear canal (control skin) and cholesteatoma epidermis and the effects on PCNA staining of subepidermal inflammatory cell infiltration of cholesteatoma were immunohistochemically studied using an antibody against PCNA. Transforming growth factor-alpha (TGF-alpha) is known to promote epidermal proliferation based on autocrine mechanism. But it is not clear that cholesteatoma epidermis is actually in the state of hyperproliferation under the effect of this growth factor. To estimate the effect of TGF-alpha on epidermal proliferation ability, the authors compared the location of PCNA and TGF-alpha in the same specimen. Unlike the control skin, not only epidermal basal cell layer and suprabasal cell layer, but also more superior layers were found to have high levels of PCNA staining in the epidermis of cholesteatoma. However, in the same cholesteatoma epidermal tissue, the PCNA staining was varied and the difference was ascribable to subepidermal cell inflammation. It appeared that the proliferation ability was high in ...Continue Reading

References

Mar 1, 1990·American Journal of Otolaryngology·J M AhnM Abramson
Jan 1, 1989·Archives of Oto-rhino-laryngology·W Y Chao, C C Huang
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Dec 1, 1981·The Journal of Experimental Medicine·Y TakasakiE M Tan
Sep 1, 1995·American Journal of Otolaryngology·M ShiwaH Moriyama
Mar 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H Sasaki, C C Huang
May 1, 1993·Acta Oto-laryngologica·J BujíaE Kastenbauer
Jan 1, 1993·The Kurume Medical Journal·N UchidaM Hirano
Mar 1, 1993·American Journal of Otolaryngology·P SchulzE Kastenbauer
Feb 1, 1996·Archives of Otolaryngology--head & Neck Surgery·H KojimaH Moriyama

❮ Previous
Next ❯

Citations

Jul 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Steven P Tinling, Richard A Chole
Jun 19, 2001·The Laryngoscope·Y A BayazítM Kanlíkama
Jun 2, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hans-J WelkoborskyMike L Hinni
Sep 10, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sertac YetiserNizamettin Aydin
Jan 27, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jerzy KuczkowskiBoguslaw Mikaszewski
Oct 16, 2004·The Kaohsiung Journal of Medical Sciences·Hung-Pin ChiShin-Meng Tsai
Aug 10, 2013·American Journal of Otolaryngology·Muzaffer OgerEmrah Sapmaz
Dec 15, 2012·The Laryngoscope·Kuen-Yao HoYu-Jen Wu
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi HaginomoriIsamu Sando
Jul 14, 2005·Acta Oto-laryngologica·Seung Hwan LeeChul Won Park
Aug 2, 2019·The Annals of Otology, Rhinology, and Laryngology·Omer J UngarYahav Oron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Sertac YetiserNizamettin Aydin
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Marianne SchmidtF Hoppe
© 2022 Meta ULC. All rights reserved