A study on plucked hair as a substrate for direct immunofluorescence in pemphigus vulgaris

Journal of the European Academy of Dermatology and Venereology : JEADV
M DaneshpazhoohC Chams-Davatchi

Abstract

It has recently been demonstrated in a study on 15 patients that plucked hair can be used as a substrate for direct immunofluorescence (DIF) in pemphigus. Our aim was to assess the sensitivity of DIF on plucked hairs in pemphigus vulgaris (PV) patients with positive DIF of oral mucosa. One hundred and ten new PV patients were enrolled in the study. They all showed the typical clinical and histological findings as well as positive DIF of the oral mucosa, diagnostic for PV. Approximately 30 hairs were obtained in the same way as for the trichogram. The hairs with their outer root sheaths (ORS) were processed for DIF in order to detect immunoglobulin G and C3. Immunodeposits favouring PV were demonstrated in the ORS of 100 cases showing a sensitivity of 91%. Regarding the relatively high sensitivity of DIF on plucked hair in PV patients with positive oral mucosal DIF in our study, it seems that hair plucking is a suitable alternative to the more invasive techniques of skin or mucosal biopsy for obtaining specimens for DIF in PV.

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Citations

Oct 19, 2012·Indian Journal of Dermatology, Venereology and Leprology·Seema ChhabraBiman Saikia
Nov 28, 2012·International Journal of Trichology·Rodrigo Pirmez
Jun 24, 2011·Journal of the American Academy of Dermatology·Maryam DaneshpazhoohCheyda Chams-Davatchi
May 25, 2011·Dermatologic Clinics·Maryia MitevaAntonella Tosti
Jan 5, 2011·Clinical and Experimental Dermatology·M KumaresanV Sandhya
May 30, 2013·The Australasian Journal of Dermatology·Srdjan TanasilovicSvetlana Popadic
Feb 18, 2015·Clinical and Experimental Dermatology·M DaneshpazhoohC Chams-Davatchi
Dec 29, 2016·Clinical and Experimental Dermatology·K VinayR W Minz
Dec 2, 2017·The British Journal of Dermatology·K E HarmanP D Yesudian
Mar 10, 2015·Expert Review of Clinical Immunology·Alireza GhanadanNima Rezaei
May 18, 2018·BioMed Research International·Marta Sar-PomianMalgorzata Olszewska
May 22, 2013·The American Journal of Dermatopathology·Adina AlexandruGeorge S Tiplica
Jun 25, 2021·Expert Review of Clinical Immunology·Ali NiliMaryam Daneshpazhooh

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