PMID: 2505943Mar 1, 1989Paper

A study on primary liver cancer in tree shrews induced by human hepatitis B virus and aflatoxin B1

Zhonghua bing li xue za zhi Chinese journal of pathology
R Q Yan

Abstract

Among 41 tree shrews exposed to aflatoxin B1(AFB1), 17 were experimental infected by human hepatitis B virus (HHBV) and 24 were uninfected. After 158 weeks, 9 cases (52.94%) of primary liver cancer (PLC) were found out of the 17 tree shrews infected by HHBV and only 3 cases (12.5%) developed PLC in the 24 uninfected animals. Significant difference of PLC incidence was seen between the HHBV-infected and uninfected groups (P less than 0.05). Moreover, 1/9 of the tree shrews that had been infected by HHBV but without exposure to AFB1 developed PLC at the 83rd week. No PLC was found in 6 tree shrews that had neither been infected with HHBV nor been exposed to AFB1. These results demonstrate the possible etiologic relationship between HHBV infection and PLC, and the synergistic effects of HHBV and AFB1 during PLC development.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Jian-Jia SuRui-Qi Yan
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Shu-sheng WangHe-min Li
Hepatobiliary & Pancreatic Diseases International : HBPD INT
Jian-Jia SuRui-Qi Yan
© 2022 Meta ULC. All rights reserved