Abstract
Seven benzimidazole compounds were synthesized and their in vitro effects on rat liver, lung and kidney microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The significant decrease in male rat liver microsomal LP level was noted only by the compound 4 at 10(-4) M (20%) and 10(-3) M (40%) concentrations whereas the other compounds were ineffective. In lung, only the compound 6 at 10(-4) M concentration exhibited significant alteration, i.e. 56% increase, in LP level. In kidney, however, apart from the compound 4, all the compounds increased LP level (35-52%) significantly. The classical antioxidant, butylated hydroxy toluene (BHT), at 10(-4) M concentration, significantly decreased LP level about 70%, in all the tissues studied. To clarify the effects of compounds 4 and 6 on LP, the responses of some CYPs, which are active in producing reactive oxygen species, to these compounds were also investigated. The compound 4 at 10(-4) and 10(-3) M concentrations inhibited the hepatic microsomal ethoxyresorufin O-deethylase (EROD) (37 and 65%) and pentoxyresorufin O-depenthylase (PROD) (14 and 62%) enzyme activities significantly. However, it did not alter the hepatic microsomal NADPH-cytochrome P450-reductase acti...Continue Reading
References
Aug 1, 1992·Pharmacogenetics·W TassaneeyakulJ O Miners
May 1, 1991·Canadian Journal of Physiology and Pharmacology·D V ParkeD F Lewis
Jan 1, 1990·Methods in Enzymology·M Hiramatsu, L Packer
Jan 1, 1990·Methods in Enzymology·V M Samokyszyn, L J Marnett
Sep 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J O PerssonM Ingelman-Sundberg
Jan 1, 1990·Free Radical Biology & Medicine·Y Sun
Jun 29, 1990·Biochemical and Biophysical Research Communications·M IscanM D Maines
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Y IscanC Safak
Jul 1, 1986·European Journal of Biochemistry·G Ekström, M Ingelman-Sundberg
Nov 1, 1987·Chemistry and Physics of Lipids·H Kappus
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J C GonderJ A Will
Sep 15, 1985·Biochemical Pharmacology·M D BurkeR T Mayer
Jun 1, 1969·The Biochemical Journal·E D Wills
Jun 1, 1971·Journal of Neurochemistry·S Bishayee, A S Balasubramanian
Jun 1, 1966·The Biochemical Journal·E D Wills
Jan 1, 1984·Critical Reviews in Toxicology·M D Maines
Mar 1, 1983·Chemico-biological Interactions·M Murray, A J Ryan
Apr 1, 1982·Biochemical Pharmacology·M Dickins, J W Bridges
Jun 1, 1982·Journal of Medicinal Chemistry·P J Little, A J Ryan
Mar 30, 1995·Chemico-biological Interactions·M PaoliniG Cantelli-Forti
Dec 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·V Nedelcheva, I Gut
Sep 1, 1994·Free Radical Biology & Medicine·H R Warner
Feb 1, 1994·Biological & Pharmaceutical Bulletin·S SogawaT Satoh
Jul 6, 1993·Biochemical Pharmacology·S OhmoriM Kitada
Jan 1, 1993·Chemical Research in Toxicology·T A Dix, J Aikens
Mar 9, 1993·Biochemical Pharmacology·J MäenpääO Pelkonen
Citations
Mar 17, 2004·Archives of Pharmacal Research·Canan KuşMümtaz Işcan
Mar 21, 2007·Investigational New Drugs·C Anil KumarKanchugarakoppal S Rangappa
Feb 3, 2012·Journal of Fluorescence·M SunitaC Gyana Kumari
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Natarajan ArumugamHoong-Kun Fun
Nov 22, 2013·PloS One·Zena A Al-MudarisAmin M S Abdul Majid
Jun 25, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zhenxing LiuShenming Zeng
Jun 15, 2012·Journal of Photochemistry and Photobiology. B, Biology·Farukh ArjmandMohd Shahid
Jan 31, 2012·Chemical Biology & Drug Design·Gülgün Ayhan-KılcıgilBenay Can-Eke
Jun 6, 2013·Archiv der Pharmazie·Emre MenteşeBahittin Kahveci
Jan 19, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Emre MenteşeBahittin Kahveci
Aug 15, 2013·Bioorganic & Medicinal Chemistry Letters·P Karuvalam RanjithN Suchetha Kumari
Nov 26, 2014·International Journal of Oncology·Zhenxing LiuShenming Zeng
Dec 15, 2010·European Journal of Medicinal Chemistry·Constantinos G NeochoritisTheodora Choli-Papadopoulou
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·F KaratasM Koca
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Çağrı KaraburunZafer Asım Kaplancıklı
Oct 7, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Zeynep Ateş-AlagözTülay Coban
Sep 29, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Gülgün Ayhan-KilcigilMumtaz Iscan
Aug 11, 2020·Journal of Biomolecular Structure & Dynamics·Oztekin AlgulSerdar Burmaoglu
Jun 23, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Hande Gurer-OrhanErdem Buyukbingol
Jan 11, 2018·Chemistry Central Journal·Bhookya ShankarVijjulatha Manga
Dec 5, 2020·Nanomaterials·Marina A TzaniIoannis N Lykakis