PMID: 9630848Jun 19, 1998Paper

A study on the antioxidant capacities of some benzimidazoles in rat tissues

Chemico-biological Interactions
B Can-EkeM Iscan

Abstract

Seven benzimidazole compounds were synthesized and their in vitro effects on rat liver, lung and kidney microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The significant decrease in male rat liver microsomal LP level was noted only by the compound 4 at 10(-4) M (20%) and 10(-3) M (40%) concentrations whereas the other compounds were ineffective. In lung, only the compound 6 at 10(-4) M concentration exhibited significant alteration, i.e. 56% increase, in LP level. In kidney, however, apart from the compound 4, all the compounds increased LP level (35-52%) significantly. The classical antioxidant, butylated hydroxy toluene (BHT), at 10(-4) M concentration, significantly decreased LP level about 70%, in all the tissues studied. To clarify the effects of compounds 4 and 6 on LP, the responses of some CYPs, which are active in producing reactive oxygen species, to these compounds were also investigated. The compound 4 at 10(-4) and 10(-3) M concentrations inhibited the hepatic microsomal ethoxyresorufin O-deethylase (EROD) (37 and 65%) and pentoxyresorufin O-depenthylase (PROD) (14 and 62%) enzyme activities significantly. However, it did not alter the hepatic microsomal NADPH-cytochrome P450-reductase acti...Continue Reading

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Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Natarajan ArumugamHoong-Kun Fun
Jun 25, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zhenxing LiuShenming Zeng
Jan 19, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Emre MenteşeBahittin Kahveci
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Çağrı KaraburunZafer Asım Kaplancıklı
Sep 29, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Gülgün Ayhan-KilcigilMumtaz Iscan
Aug 11, 2020·Journal of Biomolecular Structure & Dynamics·Oztekin AlgulSerdar Burmaoglu
Jun 23, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Hande Gurer-OrhanErdem Buyukbingol

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