A study on the dynamics of temporary HIV treatment to assess the controversial outcomes of clinical trials: An in-silico approach

PloS One
Emiliano ManciniPeter M A Sloot

Abstract

It is still unclear under which conditions temporary combined antiretroviral therapy (cART) results in a prolonged remission after interruption. Clinical trials have contradicting reposts about the effect of cART during primary HIV infection on the disease progression. Here we propose that the apparent contradiction is due the presence of a window of opportunity for cART treatment observed in the in silico studies. We study non-linear correlations in the HIV dynamics over time using information theory. This approach requires a large dataset of CD4+ T lymphocytes and viral load concentrations over time. Since it is unfeasible to collect the required amount of data in clinical trials we use C-ImmSim, a clinically validated in silico model of the HIV infection, to simulate the HIV infection and temporary cART in 500 virtual patients for a period of 6 years post infection in time steps of 8 hours. We validate the results of our model with two published clinical trials of temporary cART in acute infection and analyse the impact of cART on the immune response. Our quantitative analysis predicts a "window of opportunity" of about ten months after the acute phase during which a temporary cART has significantly longer-lasting beneficial...Continue Reading

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Citations

Mar 14, 2019·Computational and Mathematical Methods in Medicine·V PranaF Castiglione
Nov 14, 2021·BMC Bioinformatics·Paola Stolfi, Filippo Castiglione

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Software Mentioned

CASCADE
ImmSimm
ImmSim
SHM
PRIMO

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