A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats

Nephron. Experimental Nephrology
Takako YokozawaShigeru Oowada

Abstract

To investigate the effects of Hachimi-jio-gan on diabetic nephropathy, we employed an animal model, rats subjected to sub-total nephrectomy followed by streptozotocin injection, and administered Hachimi-jio-gan orally at a dose of 50, 100 or 200 mg/kg body weight/day for 15 weeks. The administration of Hachimi-jio-gan reduced dose-dependently the elevated blood glucose and urinary protein excretion levels in rats with diabetic nephropathy over the experimental period, whereas it increased creatinine clearance significantly, suggesting that Hachimi-jio-gan would prevent or delay the progression of diabetic nephropathy. In addition, the serum glycosylated protein and urea nitrogen levels were markedly elevated in rats with diabetic nephropathy compared with normal rats, and were significantly reduced by the administration of Hachimi-jio-gan, whereas Hachimi-jio-gan reversed the decrease in the serum albumin level. The serum triglyceride and total cholesterol concentrations were reduced by Hachimi-jio-gan, implying that Hachimi-jio-gan would improve the metabolic disorder of lipids caused by diabetic nephropathy. Moreover, Hachimi-jio-gan inhibited lipid peroxidation in the serum and kidney, which suggests that Hachimi-jio-gan wou...Continue Reading

Citations

Oct 1, 2011·Chinese Journal of Integrative Medicine·Bin WangCheng-lian Su
Jun 1, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chan Hum ParkTakako Yokozawa
Sep 10, 2014·Journal of Diabetes and Metabolic Disorders·Mohammad Reza ParviziMansoor Keshavarz
May 3, 2007·Biological & Pharmaceutical Bulletin·Yoshihiko HirotaniNobuo Kurokawa
Feb 13, 2016·Journal of Traditional and Complementary Medicine·Hiroshi YagiHiroshi Okada
Feb 26, 2016·Chinese Medicine·Jing-Yi LiuKalin Yan-Bo Zhang
Mar 23, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Hiroshi OkaYutaka Shimada
Jul 10, 2008·European Journal of Pharmacology·Ki Sung KangTakako Yokozawa
Aug 18, 2005·The Journal of Pharmacy and Pharmacology·Takako NakagawaNaotoshi Shibahara
Dec 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chan Hum ParkTakako Yokozawa
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Dec 10, 2015·Journal of Diabetes Research·Guang-dong SunLi-ning Miao
May 9, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·K WatanabeI Takei
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Dec 4, 2008·The American Journal of Chinese Medicine·Hyun Young KimTakako Yokozawa
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