A study on the incidence of ABL gene deletion on derivative chromosome 9 in chronic myelogenous leukemia by interphase fluorescence in situ hybridization and its association with disease progression

Genes, Chromosomes & Cancer
Dong Soon LeeHan Ik Cho

Abstract

Fluorescence in situ hybridization for the BCR/ABL rearrangement in 138 bone marrow specimens from 59 Philadelphia(+) (Ph(+)) chronic myelogenous leukemia (CML) patients, 35 Ph(+) acute lymphoblastic leukemia (ALL) patients, and 57 Ph(-) ALL patients was used. Sixteen (27.1%) of the 59 CML patients had deletions of the residual ABL gene on the derivative chromosome 9. During the study period, 32 of the 59 CML patients progressed to blast crisis or accelerated phase. Of these, nine patients had residual ABL gene deletions on the derivative chromosomes 9 and 23 patients had no deletions. The mean duration from first diagnosis to blast crisis or accelerated phase for the nine patients with ABL deletions was 32.8 months, and for the 23 patients without ABL deletions, it was 62.4 months (P = 0.017). The overall survival time for the 16 patients with deletions was 32.8 months, and for the 43 patients without deletions, it was 60.1 months (P = 0.164). ABL deletions were not detected among the 35 ALL patients (17 with major BCR/ABL, 18 with minor BCR/ABL), and it appears that this deletion occurs rarely or not at all in Ph(+) ALL patients, which is in contrast to the CML patients (27.1%). However, we detected two ALL cases with ABL del...Continue Reading

References

Apr 1, 1988·Cancer·H M KantarjianE J Freireich
May 1, 1987·Cancer Genetics and Cytogenetics·G AlimenaM Nanni
Sep 1, 1987·The American Journal of Medicine·H M KantarjianE J Freireich
Dec 1, 1994·Genes, Chromosomes & Cancer·F MertensN Mandahl
Feb 12, 1998·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M WernerM Nolte
Jul 15, 1999·The New England Journal of Medicine·S FaderlH M Kantarjian

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Citations

Apr 26, 2007·Blood·Sebastian KreilUNKNOWN German Chronic Myelogenous Leukemia (CML) Study Group
Feb 27, 2007·Cancer Genetics and Cytogenetics·Madhavi GorusuMin Fang
Jan 13, 2005·Genes, Chromosomes & Cancer·Sim-Leng TienAnn S G Lee
Mar 8, 2005·Genes, Chromosomes & Cancer·Alistair G Reid, Ellie P Nacheva
Mar 4, 2008·Genes, Chromosomes & Cancer·Doris SteinemannBrigitte Schlegelberger
Oct 3, 2006·Cancer Genetics and Cytogenetics·Nathalie Douet-GuilbertMarc De Braekeleer
May 30, 2006·Experimental and Molecular Pathology·Hon Fong L MarkYvonne Mark
Dec 13, 2005·Journal of Biochemistry and Molecular Biology·Jungeun ParkYoungsoo Kim
Dec 25, 2007·The Korean journal of laboratory medicine·Han Sung KimJin Ju Kim
Jul 7, 2010·The Korean journal of laboratory medicine·Borum SuhJong Rak Choi
Feb 6, 2004·Hematological Oncology

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