A study on the oral toxicity of mecasin in rats

Journal of Pharmacopuncture
Hohyun JeongSungchul Kim

Abstract

In this study, we investigated the oral toxicity of Gami-Jakyak Gamcho buja Decoction (Mecasin) to develop safe treatments. All experiments were conducted at the Medvill, an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate the oral toxicity of Mecasin, we administered Mecasin orally to rats. Sprague-Dawley rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of Mecasin, 500 mg/kg, 1,000 mg/kg and 2,000 mg/kg, were administered to the experimental groups, and a dose of normal saline solution, 10 mL/kg, was administered to the control group. We examined the survival rate, weight, clinical signs, and gross findings. This study was conducted under the approval of the Institutional Animal Ethics Committee. No deaths or abnormalities occurred in any of the four groups. Although slight decreases in the weights of some female rats were noted on the third day, no significant changes in weights or gross findings between the control group and the experimental groups were observed. To check for abnormalities in organs, we used microscop...Continue Reading

References

Aug 26, 2003·Mayo Clinic Proceedings·Eran Elinav, Tova Chajek-Shaul
Jun 25, 2005·The American Journal of Chinese Medicine·Tai-Hyun KangYoun-Chul Kim
Dec 23, 2008·Biochemical and Biophysical Research Communications·Li QinDuan-Fang Liao
Aug 5, 2009·Journal of Ethnopharmacology·Judith SinghuberBrigitte Kopp
Aug 19, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Kun-Shan HuangYueh-Sheng Chen
Feb 12, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun-Jung ParkInsop Shim
Sep 1, 2012·Journal of Pharmacopuncture·JaeKyoun KimSungchul Kim

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