A study on the toxicity and the biochemical effects of ethylene dibromide in the Japanese quail

British Poultry Science
G E WestlakeC H Walker

Abstract

1. The acute oral LD50 and chronic LC50 toxicity values for ethylene dibromide (EDB) were estimated for japanese quail. 2. Single sub-acute oral and intraperitoneal doses of EDB (1/2 LD50) and chronic oral doses of EDB (1/3 LC50) were administered to quail in order to characterise the sub-lethal effects of EDB residues. 3. At 24 h after sub-acute dosing, relative liver weight, plasma aspartate aminotransferase (AT) [EC 2.6.1.1] and L-iditol (sorbitol) dehydrogenase (SDH) [EC 1.1.1.14] were elevated and decreases were found in hepatic total lipid, total protein, AT and glutamic dehydrogenase (NAD (P)+) (GDH) and plasma cholinesterase (ChE) [EC 3.1.1.8] and total lipid. 4. Following chronic administration, elevations in relative liver weight, plasma ChE and total lipid, haemoglobin and haematocrit were found and hepatic AT, GDH and total lipid were decreased. 5. The changes in hepatic and plasma enzymes and constituents are discussed in relation to possible biphasic effects resulting from EDB exposure.

References

Oct 15, 1977·Biochemical Pharmacology·E Nachtomi, D S Sarma
May 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·T K With, J S Pedersen
Sep 1, 1978·Ecotoxicology and Environmental Safety·G E WestlakeP I Stanley
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·B F TrumpA U Arstila
Dec 1, 1974·Journal of Clinical Pathology·B B Bauminger
Mar 1, 1967·Medicine·T Barka, H Popper
Mar 1, 1969·Journal of Clinical Pathology·P Trinder
Sep 1, 1980·Journal of Agricultural and Food Chemistry·A E Hagerman, L G Butler
Sep 1, 1954·American Journal of Clinical Pathology·M M STRUMIAE D HART
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Jul 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·E van KAMPEN, W G ZIJLSTRA

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