A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis

International Journal of Dermatology
David Paslin, Philip Wertz

Abstract

Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalizes ceramide levels. Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment. Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal. These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti-inflammatory actions rather than to any restorative effect on stratum corneum ceramides.

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Citations

Jun 23, 2009·Current Opinion in Pediatrics·P Chris Anderson, James G Dinulos
May 3, 2006·International Journal of Dermatology·David Paslin, Esther Krug
Feb 24, 2016·Surgical Neurology International·Francesca GrazianoDomenico Gerardo Iacopino
May 20, 2015·Surgical Neurology International·Francesca GrazianoDomenico G Iacopino
Jul 23, 2013·Contact Dermatitis·Jakob Mutanu Jungersted, Tove Agner
Nov 25, 2011·Small·Lucyanna Barbosa-BarrosOlga López

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