A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction

Prostaglandins
M CirinoB B Vargaftig

Abstract

The involvement of platelet activating factor (PAF) in anaphylaxis was examined by recording the pulmonary responses of anesthetized passively sensitized guinea-pigs to the aerosolization of ovalbumin. Animals were tested with and without BN 52021 (a ginkgolide B, PAF receptor antagonist) pretreatment. Aerosolization of ovalbumin produced a bronchoconstriction (BC) which could be made refractory to additional challenges with the antigen. In animals desensitized to ovalbumin, aerosolization of PAF produced an unattenuated BC. Guinea pigs desensitized by repeated aerosolizations of PAF subsequently showed reduced responses to aerosolized antigen suggesting that PAF may be involved in the BC. Animals pretreated with BN 52021, were protected against the effects of systemically administered PAF and also showed reduced responses to aerosolized antigen. Aerosolization of the leukotriene antagonist, FPL 55712, was ineffective against anaphylactic BC under conditions where catecholamine and histamine release were blocked.

References

Aug 30, 1985·Biochemical and Biophysical Research Communications·I Maridonneau-PariniB B Vargaftig
Jan 1, 1984·Agents and Actions·M O'Donnell, A F Welton

❮ Previous
Next ❯

Citations

Nov 1, 1990·The American Review of Respiratory Disease·J W WatsonH J Showell
Jan 1, 1987·British Journal of Pharmacology·M Criscuoli, A Subissi
Mar 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S H LeirH Y Lei
Nov 11, 2019·Seminars in Immunopathology·Susetta Finotto
May 1, 1989·Biochemical Pharmacology·M PretolaniB B Vargaftig
Apr 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W T de LimaS Jancar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.