PMID: 9188649Jul 1, 1997Paper

A subgenomic mRNA transcript of the coronavirus mouse hepatitis virus strain A59 defective interfering (DI) RNA is packaged when it contains the DI packaging signal

Journal of Virology
E C BosW J Spaan

Abstract

In infected cells, only the genomic RNA of the coronavirus mouse hepatitis virus strain A59 (MHV-A59) is packaged into the virions. In this study, we show that a subgenomic (sg) defective interfering (DI) RNA can be packaged into virions when it contains the DI RNA packaging signal (DI RNA-Ps). However, the sg DI RNA is packaged less efficiently than the DI genomic RNA. Thus, while specificity of packaging of RNAs into MHV-A59 virions is determined by the DI RNA-Ps, efficiency of packaging is determined by additional factors.

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Citations

Jul 13, 2007·Journal of Virology·Patricia EifartAndreas Herrmann
Aug 28, 2003·Journal of Virology·Volker ThielStuart G Siddell
Jan 28, 2005·The Biochemical Journal·Gerco HassinkEmmanuel Wiertz
Mar 9, 2000·Journal of Virology·R MolenkampE J Snijder
Dec 10, 1999·Journal of Virology·R Cologna, B G Hogue
Mar 2, 2013·Journal of Virology·Lili Kuo, Paul S Masters

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