A subgroup of patients with chronic pancreatitis overexpress the c-erb B-2 protooncogene

Annals of Surgery
H FriessM Korc

Abstract

Chronic pancreatitis (CP) is a chronic condition associated with pancreatic fibrosis. A small subgroup of patients with CP develop enlargement of the head of the pancreas (EHP). This study examined some of the mechanisms that may lead to the development of EHP. The c-erb B-2 protooncogene encodes a 185-kDa transmembrane growth factor receptor (p185) that regulates cell growth and differentiation. The authors analyzed c-erb B-2 expression in samples obtained from the head of the pancreas from 26 patients with CP (5 women, 21 men) using immunohistochemical and molecular technique. A diagnosis of CP with EHP was made when the vertical pancreatic head diameter was greater than 4 cm (14 patients), as determined by contrast-enhanced computed axial tomography scan. Pancreatic tissues from 15 healthy organ donors served as control subjects. In all patients without EHP and in the healthy control subjects, p185 immunoreactivity was present at low levels. In contrast, strong p185 immunoreactivity was observed in acinar and ductal cells in all patients with EHP. By in situ hybridization, c-erb B-2 messenger ribonucleic acid (mRNA) grains were expressed at high levels in patients with CP with EHP in both ductal and acinar cells. Northern bl...Continue Reading

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Citations

Oct 24, 1998·Gastroenterology·H FriessP Malfertheiner
May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Günter Klöppel
Mar 30, 2002·Annals of Surgery·Peter BalazMarkus W Büchler
Jul 17, 1998·Transplantation·W H TangM W Büchler
Jul 23, 1999·Annals of the New York Academy of Sciences·M A Hollingsworth
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·K KiehneK H Herzig
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·P BalazM W Büchler
Dec 17, 2009·BMC Gastroenterology·Markus W BüchlerPeter Malfertheiner
Jul 13, 2000·Biochemical and Biophysical Research Communications·Z ZhuM Korc
Nov 9, 2005·Seminars in Diagnostic Pathology·Günter Klöppel
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·H FriessM W Büchler
Jun 5, 2007·International Journal of Cancer. Journal International Du Cancer·Hana AlgülRoland M Schmid
Apr 25, 2003·Langenbeck's Archives of Surgery·Mark HartelMarkus W Büchler

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