A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage

European Journal of Immunology
Thomas BarthlottGeorg A Holländer

Abstract

Regulatory T (Treg) cells are pivotal for the maintenance of peripheral tolerance by controlling self-reactive, chronic, and homeostatic T-cell responses. Here, we report that the increase in Treg-cell suppressive function observed in lymphopenic mice correlates with the degree of lymphopenia and is caused by a higher frequency of a novel subpopulation of CD103(pos) ICOS(pos) Treg cells. Though present in the thymus, CD103(pos) ICOS(pos) Treg cells are not generated there but recirculate from the periphery to that site. The acquisition and maintenance of this distinctive phenotype requires the LN microenvironment and the in situ availability of antigen. Contrary to conventional effector and other Treg cells, the cellularity of CD103(pos) ICOS(pos) Treg cells is not affected by the absence of IL-7 and thymic stroma lymphopoetin. Given their increased frequency in lymphopenia, the absolute number of CD103(pos) ICOS(pos) Treg cells remains unchanged in the periphery irrespective of a paucity of total Treg cells. We furthermore demonstrate, with cell transfers in mice, that the CD103(pos) ICOS(pos) phenotype represents a LN-specific differentiation stage arrived at by several other Treg-cell subsets. Thus, tissue-specific cues dete...Continue Reading

References

Apr 1, 1995·The Journal of Experimental Medicine·U von Freeden-JeffryR Murray
Jan 14, 1994·Cell·K A HogquistF R Carbone
Dec 12, 2001·Nature Immunology·Marc A GavinAlexander Rudensky
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joachim LehmannAlf Hamann
Aug 27, 2003·The Journal of Experimental Medicine·Sylvain FissonBenoît L Salomon
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristina CozzoAndrew J Caton
Jun 9, 2004·The Journal of Experimental Medicine·Ann E HermanChristophe Benoist
Jul 21, 2004·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Aug 17, 2004·Immunity·Chyi-Song HsiehAlexander Y Rudensky
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Terry J Fry, Crystal L Mackall
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 12, 2005·The Journal of Experimental Medicine·Oliver AnnackerFiona Powrie
Oct 18, 2005·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 16, 2006·Blood·Shuang WeiWeiping Zou
Jun 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tom KrupicaCrystal L Mackall
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nabil BoscoRhodri Ceredig
Feb 3, 2007·International Immunology·Magdalena J PolanczykHalina Offner
Mar 21, 2007·The Journal of Experimental Medicine·Martin A SchneiderAntal Rot
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey L StephensEthan M Shevach
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yvonne BurmeisterAndreas Hutloff
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura StraussTheresa L Whiteside
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoxi ChenHung-Sia Teh
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Celine S LagesClaire Chougnet
Oct 11, 2008·Science·Kajsa WingShimon Sakaguchi
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunil K ChauhanReza Dana
Apr 4, 2009·Current Opinion in Immunology·Elodie Segura, José A Villadangos
Oct 3, 2009·Science·Ashutosh ChaudhryAlexander Y Rudensky
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janine SuffnerGünter J Hämmerling
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Markus FeuererChristophe Benoist

❮ Previous
Next ❯

Citations

Jul 30, 2016·Journal of Autoimmunity·Carla LippensStéphanie Hugues
Apr 29, 2016·Clinical and Experimental Immunology·A L Rodríguez-PereaP A Velilla
Dec 18, 2018·Frontiers in Immunology·Carla LippensStéphanie Hugues
Jun 5, 2021·Communications Biology·Bergithe E OftedalGeorg A Holländer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.