A subset of CD8+ T cells from allergic patients produce IL-4 and stimulate IgE production in vitro

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
N MeissnerH Renz

Abstract

A subset of IL-4 producing CD8+ T cells was recently identified in HIV patients. Based on these findings we examined whether IL-4 producing CD8+ T cells would also be present in allergic patients and what would be the functional relevance of this T-cell population. We investigated the role of CD8+ T cells in IgE production of allergic diseases by analysing the cytokine profile of individual CD4+ and CD8+ T cells. In allergic patients about twice as many CD4+ T cells and six times as many CD8+ T cells produced IL-4 as in non-allergic controls. In contrast the frequency of IFNgamma+ T-cell subsets did not significantly differ between the allergic and non-allergic individuals. The frequency of IL4+ CD8+ T cells correlated with the level of serum IgE. Coculture experiments with T cells or purified CD8+ T cells together with autologous B cells indicated that CD8+ T cells enhanced IgE in vitro, but not IgM production, even when they were physically separated from B cells. This effect could be partially blocked by addition of an IL-4 binding protein, a soluble IL-4 receptor indicating that IL-4 is involved in CD8+ T-cell mediated IgE production. These data indicate a positive role of IL-4 secreting CD8+ T cells in IgE regulation in al...Continue Reading

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Citations

Jan 23, 1999·Current Opinion in Immunology·D M Kemeny
Jan 20, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O M Kon
May 2, 2003·Immunological Investigations·C S WaltersS Paluvoi
Jul 26, 2003·The Journal of Investigative Dermatology·Chiung Hui HuangKaw Yan Chua
Aug 13, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chi-Ling FuBor-Luen Chiang
Jul 7, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L R CrackG S Ogg
Mar 6, 2012·The Journal of Allergy and Clinical Immunology·Yafang TangDavid M Kemeny
Jun 25, 2010·Current Opinion in Pharmacology·Shyam S MohapatraGary Hellermann
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M O'BrienW R Thomas
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J PrietoJ Grunewald
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T JungC Neumann

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