A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut

FEBS Letters
Jeong-Ho ParkJae Young Kwon

Abstract

The intestine is involved in digestion and absorption, as well as the regulation of metabolism upon sensation of the internal intestinal environment. Enteroendocrine cells are thought to mediate these internal intestinal chemosensory functions. Using the CaLexA (calcium-dependent nuclear import of LexA) method, we examined the enteroendocrine cell populations that are activated when flies are subjected to various dietary conditions such as starvation, sugar, high fat, protein, or pathogen exposure. We find that a specific subpopulation of enteroendocrine cells in the posterior midgut which express Dh31 and tachykinin are activated by the presence of proteins and amino acids.

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Citations

Jul 9, 2016·Current Opinion in Genetics & Development·Zheng GuoBenjamin Ohlstein
Oct 11, 2019·Cellular and Molecular Life Sciences : CMLS·Yu-Chieh David Chen, Anupama Dahanukar
Jun 23, 2020·EMBO Reports·Maja C FunkMichael Boutros
Aug 23, 2020·Cell and Tissue Research·Dick R Nässel, Meet Zandawala
Oct 6, 2018·Genetics·Irene Miguel-AliagaBruno Lemaitre
Jul 31, 2019·Cell and Tissue Research·Silvia CacciaGianluca Tettamanti
Dec 12, 2019·Frontiers in Neuroscience·Dick R NässelHonoo Satake
May 3, 2020·Cellular and Molecular Life Sciences : CMLS·Gérard ManièreYael Grosjean

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