PMID: 8953470Dec 1, 1996Paper

A subset of estrogen receptor-containing neurons project to the median eminence in the ewe

Journal of Neuroendocrinology
H T JansenM N Lehman

Abstract

The neural pathways responsible for conveying the steroid feedback signals that ultimately affect reproductive neuroendocrine function remain largely undefined. One possibility involves a direct projection from estrogen receptor (ER)-containing neurons to the median eminence (ME), a site of neuroendocrine peptide release. To examine this possibility, 8 ewes received stereotaxic injections of the retrograde neuronal tract-tracing compound cholera toxin-beta subunit (CT beta) into the ME. Neurons sending projections to the ME and containing ER were identified using a dual-label immunoperoxidase method. Double-labeled cells were found in distinct regions: (1) the ER-rich arcuate nucleus (ARC) that contained the greatest number of double-labeled cells, and (2) the organum vasculosum of the lamina terminalis (OVLT) which contained a very consistent, but low, number of double-labeled cells. While a fairly large number of retrogradely-labeled ARC neurons containing ER were identified, the majority of ER-containing ARC neurons were unlabeled and thus send projections elsewhere. Other regions containing high concentrations of ER-positive cells such as the medial preoptic area (MPOA), anterior hypothalamic area, and ventrolateral portion...Continue Reading

References

Aug 1, 1989·Neuropeptides·J AntonopoulosH Michaloudi
Jan 1, 1988·Brain Research Bulletin·M N LehmanA J Silverman
Jan 1, 1987·Journal of Steroid Biochemistry·S P KalraW R Crowley
Jan 1, 1987·Annals of the New York Academy of Sciences·M N LehmanA J Silverman
Feb 1, 1984·Biological Reviews of the Cambridge Philosophical Society·G B Martin
Jul 1, 1980·The Journal of Comparative Neurology·S J Wiegand, J L Price

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Citations

Jan 1, 1997·Brain Research Bulletin·M N LehmanH T Jansen
Jun 14, 2000·Animal Reproduction Science·C J ScottI J Clarke
Jun 10, 2000·Journal of Neuroendocrinology·C E RoselliJ A Resko
Feb 13, 2007·Physiology & Behavior·Heiko T JansenGary A Iwamoto
Dec 18, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·K S RiganoH T Jansen

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