PMID: 8600778Apr 1, 1995Paper

A subset of macrophages located along the basement membrane ("lining cells") is a characteristic histopathological feature of psoriasis

The American Journal of Dermatopathology
W H BoehnckeW Sterry

Abstract

In this paper, we describe the immunophenotype and ultrastructure of a new macrophage subpopulation present in inflamed but not in normal human skin. In biopsy material from patients with psoriasis (n = 4), atopic dermatitis (n = 4), and positive patch test reactions (n = 4), spindle-shaped macrophages located along the basement membrane were detected staining positive for CD11c (LeuM5 high, Ki-M1 low), CD68 (Ki-M6 low), and Ki-M8 (low). This subpopulation was most prominent in psoriasis, where a median of 34 macrophages neighbored 100 basal keratinocytes, thus covering about 80% of the dermoepidermal junction. The numbers of atopic and positive patch test reactions were 11 and 13, respectively, accounting for about 20% of the dermoepidermal junction. Transmission electron microscopy revealed an electron-lucent nucleus with dense deposits of chromatin along the nuclear membrane. Interruptions of the integrity of the basement membrane neighboring these cells were also seen. We repeatedly observed parts of basal keratinocytes merging through these openings and macrophages exhibiting cytoplasmic extentions directed toward the porus. Our observations suggest vigorous interactions between macrophages and basal keratinocytes and supp...Continue Reading

Citations

May 11, 2010·Archives of Dermatological Research·Rishi NigamKlas Nordlind
Dec 17, 2009·Expert Reviews in Molecular Medicine·Emoke Rácz, Errol P Prens
Aug 4, 2006·The Journal of Clinical Investigation·Athanasios StratisIngo Haase
Aug 4, 2006·The Journal of Clinical Investigation·Rachael A Clark, Thomas S Kupper
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Brian J NickoloffMark W Lingen
Aug 16, 2011·Pharmacology & Therapeutics·Pim J KoelinkAletta D Kraneveld
Aug 30, 2008·Clinics in Dermatology·Yi-Yang Yvonne LiMichael P Schön
Nov 21, 2007·Clinics in Dermatology·Wolf-Henning Boehncke, Michael P Schön
Jun 19, 2008·Experimental Dermatology·Michael P Schön
Apr 4, 2009·The American Journal of Pathology·Julie A WolframNicole L Ward
Oct 12, 2018·Scandinavian Journal of Immunology·Silje M SolbergSilke Appel
Mar 3, 2010·The British Journal of Dermatology·J P McFaddenL Fry
Feb 3, 2005·Nature Reviews. Drug Discovery·Alice B Gottlieb
Sep 9, 2015·Scandinavian Journal of Immunology·John P McFadden, Ian Kimber
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Apr 10, 2014·Cell Adhesion & Migration·Christiane WiesnerStefan Linder

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