A substance P projection from the superior colliculus to the parabigeminal nucleus in the rat and hamster.

Brain Research
C Bennett-ClarkeR W Rhoades

Abstract

Immunocytochemical staining with antisera directed against substance P (SP) demonstrated the existence of numerous immunoreactive neurons throughout the mediolateral and rostrocaudal extents of the stratum griseum superficiale (SGS) of the superior colliculus (SC) of both rat and hamster. In both of these species, very dense SP-like immunoreactivity (SPLI) was also visible in the parabigeminal nucleus. Combination of retrograde tracing with True blue or Fluorogold and immunocytochemistry demonstrated that SP-positive SC neurons projected to the parabigeminal nucleus in both hamster and rat. Retrogradely labelled and double-labelled cells were most numerous in the rostromedial portion of the SC and rare in the caudal portion of the colliculus. Destruction of the superficial layers of the SC resulted in a virtually complete loss of SPLI in the ipsilateral parabigeminal nucleus in both species. SPLI was also visible in two other targets of the superficial SC laminae: the intergeniculate leaflet and the ventral lateral geniculate nucleus. Ablation of the dorsal SC laminae did not reduce SPLI in either of those nuclei. Our results thus indicate that at least some tectoparabigeminal neurons in hamster and rat contain SPLI and further...Continue Reading

References

Aug 15, 1976·The Journal of Comparative Neurology·Y C Tiao, C Blakemore
Jun 27, 1975·Brain Research·S Kawamura, E Kobayashi
Mar 15, 1976·Experimental Brain Research·T L Hickey, P D Spear
Dec 15, 1974·The Journal of Comparative Neurology·T P Langer, R D Lund
May 4, 1981·Brain Research·V Holcombe, W C Hall
Dec 30, 1983·Neuroscience Letters·S SugitaK Terasawa
May 10, 1982·The Journal of Comparative Neurology·J A Stevenson, R D Lund

❮ Previous
Next ❯

Citations

Oct 1, 1996·Progress in Neurobiology·A K MoschovakisS M Highstein
Mar 12, 2002·The European Journal of Neuroscience·Ruth IzraeliZvi Wollberg
Dec 24, 1990·Brain Research·R D MooneyR W Rhoades
Aug 22, 2001·Microscopy Research and Technique·E A Debski
Feb 6, 1995·The Journal of Comparative Neurology·F A WhiteR W Rhoades
Oct 2, 1995·The Journal of Comparative Neurology·E A DebskiA M Chapman
Aug 10, 2019·The Journal of Comparative Neurology·Kyle L WhylandMartha E Bickford
Jul 8, 1993·The Journal of Comparative Neurology·R D LaneR D Mooney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.