PMID: 3229493Sep 1, 1988

A substance with antibacterial and antifungal activity. IV. Synthesis and microbiological activity of new 1,5-diarylpyrrole derivatives

Il Farmaco; edizione scientifica
M ScalzoN Simonetti

Abstract

The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that only carboxamide derivatives exhibit satisfactory antifungal activity. By contrast all tested compounds show very poor antibacterial activity. The displacement of NO2 group from para to meta or ortho position of the aryl at C5 of the pyrrole ring affects the antimicrobial activity.

Related Concepts

Microbicides
Antibiotics, Antifungal
Fungus Drug Sensitivity Tests
Pyrroles
Structure-Activity Relationship

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