A subtoxic interactive toxicity study of ethanol and chromium in male Wistar rats

Alcohol
S AcharyaC V Rao

Abstract

The purpose of this study was to evaluate the interactive toxicity of ethanol with potassium dichromate (K2Cr2O7-chromium). Young, male Wistar rats (100-120 g) were divided into four groups of five or six animals each and were dosed, through water, with 10% ethanol (vol./vol.) or 25 ppm chromium or were dosed with a combination of ethanol+chromium at the same concentrations for a period of 22 weeks ad libitum and were maintained on normal diet. Control animals were maintained on a normal diet and water for the same period. The serum succinate dehydrogenase and liver total triglyceride levels were significantly reduced in the three treated groups. The serum alkaline phosphatase levels were significantly reduced in ethanol-treated rats, and there was no significant change in the acid phosphatase activity. Serum aspartate and alanine aminotransferase levels in the three treated groups were significantly increased. The liver glycogen significantly decreased in both the ethanol-treated and the chromium-treated rats. There was a significant increase in liver total cholesterol levels in chromium-treated rats. Total glutathione levels were significantly decreased in the livers of ethanol-treated and ethanol+chromium-treated rats. To fu...Continue Reading

References

Sep 1, 1992·Journal of Toxicology and Environmental Health·E BermanJ E Simmons
Jun 23, 1992·Biochemical Pharmacology·M P Murphy, K F Tipton
Jan 1, 1991·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J R NationC A Grover
Oct 1, 1991·British Journal of Industrial Medicine·N BeckerR Frentzel-Beyme
Jan 1, 1991·Alcohol·J R NationG R Bratton
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P D HallM J Cousins
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·G Y Sun, A Y Sun
Mar 1, 1986·Annals of Internal Medicine·L B SeeffS B Benjamin
Jul 16, 1973·Life Sciences·R Blomstrand, L Kager
Dec 1, 1983·Scandinavian Journal of Work, Environment & Health·E Lindberg, O Vesterberg
Sep 28, 1984·Biochemical and Biophysical Research Communications·M E MailliardD J Tuma
Jun 1, 1983·Scandinavian Journal of Work, Environment & Health·I FranchiniA Mutti
Feb 1, 1983·Toxicology and Applied Pharmacology·C HétuJ G Joly
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L G Lange
Nov 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Nov 1, 1993·Alcohol·J C Fernández-ChecaN Kaplowitz
Sep 1, 1993·Alcohol·C A GroverG R Bratton
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Sep 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·F GALLETTI

❮ Previous
Next ❯

Citations

Aug 21, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Wylly Ramsés García-NiñoJosé Pedraza-Chaverrí
May 26, 2016·Journal of Advanced Research·M O ElshazlySahar S Abd El-Rahman
Jun 2, 2015·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Chantelle VenterMegan J Bester
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wylly Ramsés García-Niño, José Pedraza-Chaverrí
Jun 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haiyan ZhuXinxin Liu
Nov 30, 2013·Environmental Science and Pollution Research International·Xijin XuXia Huo
May 1, 2010·Chemico-biological Interactions·Kristen P NickensSusan Ceryak
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Richard M SedmanRobert Howd
Jun 1, 2018·Journal of the Science of Food and Agriculture·Soraia YounanHermann Bremer-Neto
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Azar Hosseini, Hossein Hosseinzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.