A successfully treated malignant melanoma arising in a large congenital vulvar blue nevus.

Dermatologic Therapy
Weizhao LinXuefeng Jiang

Abstract

An atypical cellular blue nevus, a benign mass, may sometimes transform into a malignant melanoma. Here, we report a rare case of melanoma arising in a large congenital vulvar blue nevus. A 28-year-old Chinese woman presented to our hospital with a chief complaint of a vulvar mass that had persisted for 8 years. The patient underwent extensive local excision, followed by reconstructive surgery of the female reproductive tract. The mass was diagnosed as being a vulvar malignant melanoma. Postoperatively, the patient received interferon immunotherapy and recovered without complications. No evidence of recurrence was observed after 32 months of follow-up. Our case thus shows that comprehensive treatment with surgery supplemented by immunotherapy can be effective against a malignant melanoma arising in a vulvar blue nevus.

References

Dec 17, 2008·The Lancet Oncology·Benjamin Piura
Nov 26, 2010·Obstetrics and Gynecology·Michael FrumovitzPedro T Ramirez
Mar 22, 2014·Cancer Biology & Therapy·Martina SanlorenzoSusanna Ortiz-Urda
Sep 1, 2016·Anais Brasileiros De Dermatologia·Camila Sampaio RibeiroThiago Jeunon
Aug 30, 2017·Mediators of Inflammation·Carmen Rodríguez-CerdeiraRoberto Arenas Guzman
Jul 28, 2019·Journal of the American Academy of Dermatology·Andrea TanMiriam K Pomeranz

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