A sugar-lectin rich interface between soft tissue and the stiff byssus of Atrina pectinata.

Biomaterials Science
Jimin ChoiDong Soo Hwang

Abstract

Maintaining durable adhesion between soft tissues and relatively hard implant materials is one of the most elusive technological difficulties in bionic devices due to contact damage between mechanically mismatched materials. Although there are many examples of coexistence of soft and hard tissues in living organisms, relatively little is known about the mechanisms used to overcome mechanical mismatches occurring at the interface between soft and hard tissues. Among the various creatures possessing mechanically mismatched biological tissues, Atrina pectinata is a good model system where the interface between stiff byssal threads and soft tissues is distributed all over an extended organ. In this study, we found a wide distribution of various types of carbohydrates and lectins at the mechanically mismatched interface of the byssus of Atrina using histological methods and proteomics. Reversible and robust interactions between the carbohydrate and lectins at the interface would play a major role in mitigating the contact damage at the Atrina interface. Based on these results, the adhesion between sugar and lectin would be useful to overcome a wide range of contact damage observed in research studies on bionic devices.

References

Oct 1, 1986·The Journal of Experimental Zoology·J M Mascolo, J H Waite
Aug 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M R Green, J V Pastewka
Jul 1, 1983·Journal of Clinical Pathology·A Leathem, N Atkins
Nov 25, 2003·Analytical Chemistry·Alexey I NesvizhskiiRuedi Aebersold
Feb 16, 2005·Nature Materials·V ImbeniR O Ritchie
Apr 5, 2007·Nature Protocols·Andrej ShevchenkoMatthias Mann
Dec 7, 2007·The Journal of Experimental Biology·Matthew J Harrington, J Herbert Waite
May 5, 2009·The Journal of Experimental Biology·Trevor Pearce, Michael Labarbera
Mar 6, 2010·Science·Matthew J HarringtonPeter Fratzl
May 11, 2010·Genomics, Proteomics & Bioinformatics·Yupeng Zhao, Yen-Han Lin
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hongbo ZengJ Herbert Waite
Feb 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Niels Holten-AndersenJ Herbert Waite
May 29, 2014·Nature Communications·Benny Bar-OnYael Politi
Dec 3, 2016·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Dec 10, 2016·Science·Canan Dagdeviren
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Jun 28, 2018·Soft Matter·Delphine PascheMatthew James Harrington
Jan 4, 2019·Nature Communications·Maksim KunitskiReinhard Dörner
Sep 10, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Fan ZengUte Rothbächer

❮ Previous
Next ❯

Citations

Apr 6, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael A McCartney

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
acetylation
dissection

Software Mentioned

Atrina
Scaffold
Proteome
SEQUEST
Conserved Domain Search Service ( CD - search )

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.