A sulfatide receptor distinct from L-selectin is involved in lymphocyte activation

FEBS Letters
Z DingM Miyasaka

Abstract

Sulfatide induces leukocyte activation, which is thought to be mediated via L-selectin. Here we demonstrate that lymphocytes express a receptor for sulfatide distinct from L-selectin and that this receptor is involved in sulfatide-induced cell activation. While cell surface L-selectin expression was abolished by phorbol 12-myristate 13-acetate (PMA), lymphocytes retained the ability to bind sulfatide in liquid phase as well as in immobilized solid phase. The novel sulfatide receptor obtained from PMA-treated lymphocytes showed a molecular size of 65 kDa. Stimulation through this receptor triggered cytosolic free Ca2+ elevation and intercellular aggregation.

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Citations

Apr 18, 2008·Journal of Virology·Tadanobu TakahashiTakashi Suzuki
Feb 15, 2005·Biochimica Et Biophysica Acta·Roger SandhoffHermann-Josef Gröne
Jan 8, 1999·The Journal of Surgical Research·K UedaS Tajima
Jun 23, 2000·The Journal of Surgical Research·J AkamatsuM Nozawa
Jan 25, 2000·The Journal of Surgical Research·K UedaS Tajima
Sep 14, 2007·European Journal of Immunology·Pascal DuchesneauThomas K Waddell

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