PMID: 726512Nov 1, 1978Paper

A sulphate metabolite of trimethoprim in goats and pigs

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
P Nielsen, L Dalgaard

Abstract

1. Urine from goats and pigs after intravenous administration of [14C]trimethoprim contained an unidentified fraction of 'other water-soluble metabolites'. This fraction accounts for 56% of the administered dose in goat urine and 65% in pig urine. 2. A sulphate metabolite comprising the major part of the latter fraction in both goat and pig urine was isolated by gel filtration and paper chromatography and identified by spectroscopic methods as 2,4-diamino-5-(3,4-dimethoxy-5-sulphooxybenzyl)pyrimidine. 3. No hydrolysis of the sulphate metabolite occurred on treatment with aryl sulphatase from (a) Helix pomatia, (b) limpets and (c) Aerobacter aerogenes, while treatment with aryl sulphatase from abalone entrails led to very slow hydrolysis.

References

Feb 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Feb 1, 1976·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
May 1, 1974·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J J MillerC G Curtis
Apr 1, 1973·Journal of Pharmaceutical Sciences·C W Sigel, D A Brent
Nov 1, 1973·The Journal of Infectious Diseases·C W SigelC A Nichol
Mar 1, 1970·Journal of Pharmaceutical Sciences·S A KaplanK Alexander

Citations

Nov 1, 1987·Pharmacology & Toxicology·P NielsenW J Xia
Dec 30, 2014·Journal of Pharmacological and Toxicological Methods·Lars Dalgaard
Sep 2, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn
Nov 1, 1984·Acta Pharmacologica Et Toxicologica·N Gyrd-HansenF Rasmussen

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