PMID: 6540737Aug 1, 1984Paper

A sulphite oxidase-deficient rat model: reproductive toxicology of sulphite in the female

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L DulakA F Gunnison

Abstract

The reproductive toxicology of sulphite was investigated in female rats with induced deficiencies of sulphite oxidase. Induction of sulphite oxidase deficiency was accomplished by administration of a diet with a high tungsten to molybdenum ratio. This animal model was chosen because it enables exposure of tissues to high systemic sulphite concentrations without debilitating side effects. The reproductive performance of female sulphite oxidase-deficient rats, exposed continuously to sulphite from about 3 wk before mating until the experiment was terminated on day 20 of gestation, was compared to that of unexposed rats with normal sulphite oxidase activity. There was no treatment-related trend in any of the parameters observed, including mating and pregnancy rates, gestational weight gain, pre-implantation loss, resorbed and dead foetuses, litter size, foetal weight and malformations. Of the spectrum of malformations observed in control and treated animals, only anophthalmia may have been treatment related. From these experiments, performed in an animal model that is a conservative metabolic analogue for man, we have concluded that there is no evidence to indicate that exposure of females to sulphite poses a significant reproduct...Continue Reading

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Citations

Jun 24, 2010·Journal of Physiology and Biochemistry·Oktay Hasan OzturkVural Kucukatay
Mar 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J Wever
Jan 1, 1985·Food Additives and Contaminants·R Walker
Sep 27, 2006·The International Journal of Neuroscience·Yaşar Gül OzkayaMehmet Zülküf Onal
Jun 20, 2012·Neurochemistry International·Erdogan KocamazVural Kucukatay
Feb 1, 2005·Neurotoxicology and Teratology·Vural KüçükatayAysel Ağar
Oct 10, 2008·Toxicology and Industrial Health·V KüçükatayH Bagci
Sep 1, 1986·Zeitschrift für Ernährungswissenschaft·J Wever

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