PMID: 9178195May 1, 1997Paper

A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils

The Journal of Pharmacy and Pharmacology
M VasängeL Bohlin

Abstract

The South American fern Polypodium decumanum, traditional name calaguala, has documented clinical use in oral treatment of skin disorders, including psoriasis. The inflammatory mediator platelet-activating factor (PAF), has been implicated in the pathogenesis of psoriasis. A constituent of a calaguala extract has been shown to have inhibitory activity in a PAF-induced exocytosis model in human neutrophils. The compound was identified as the sulphoquinovosyl diacylglycerol 1,2-di-O-palmitoyl-3-O-(6-sulpho-alpha-D-quinovopyranosyl)-glycero l by spectroscopic means. When subsequently studied in an in-vitro model for [3H]PAF binding in neutrophils from man the compound caused dose-dependent displacement of [3H]PAF from its receptor with an IC50 value of 2 microM. It is suggested that the compound acts through PAF receptor antagonism in intact human neutrophils.

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Citations

Oct 16, 2003·British Journal of Pharmacology·Rossana EstellésMaria-Jesús Sanz
Sep 14, 2012·Pharmaceutical Biology·Arshdeep Kaur, Suresh Kumar
Jun 10, 2005·Journal of Leukocyte Biology·Rossana EstellésMaría-Jesús Sanz
Sep 1, 2005·Journal of Leukocyte Biology·Rossana EstellésMaría-Jesús Sanz

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