PMID: 75232Jan 1, 1978Paper

A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression

The Journal of Experimental Medicine
E G EnglemanH O McDevitt

Abstract

It has previously been shown that J.H., a human leukocyte antigen (HLA)-Dw2 homozygous multiparous woman, fails to respond in a mixed lymphocyte reaction (MLR) to her Dw1 homozygous husband W.H., and that her T cells suppress the responses of HLA matched responders to W.H. The present studies take advantage of the observation that J.H. suppressor cells resist a dose of gamma-irradiation which functionally eliminates her MLR responder cells. J.H. cells, depleted of alloreactive cells, suppress the responses of Dw2 heterozygous or homozygous cells to W.H., regardless of their associated HLA-A or B antigens. Only when W.H. or a few other cells are present as the irradiated stimulator is J.H. suppression of Dw2 responses detected. Thus, the J.H. suppressor T cell recognizes determinants in the irradiated stimulator cells as well as D locus products in the responder.

Citations

Feb 1, 1981·Human Immunology·N E GoekenS Brown
May 31, 1979·Nature·J Silver, S Ferrone
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J StrelkauskasS F Schlossman
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P A Neighbour, B R Bloom
Jul 1, 1982·The Journal of Experimental Medicine·K OkudairaR C Williams
Apr 1, 1978·Tissue Antigens·E Thorsby
Jan 1, 1979·Immunological Reviews·J W Streilein
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Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Gérard ChaouatNathalie Ledée
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Feb 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·M Onsrud
Apr 5, 2019·Journal of Reproductive Immunology·Gerard Chaouat

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