A Supramolecular Approach for Enhanced Antibacterial Activity and Extended Shelf-life of Fluoroquinolone Drugs with Cucurbit[7]uril

Scientific Reports
Hamdy S El-SheshtawyJyotirmayee Mohanty

Abstract

The host-guest interactions of a third-generation fluoroquinone, danofloxacin (DOFL), with the macrocyclic host cucurbit[7]uril (CB7) have been investigated at different pH values (~3.5, 7.5, and 10). The photophysical properties have been positively affected, that is, the fluorescence yield and lifetime increased, as well as the photostability of DOFL improved in the presence of CB7. The antibacterial activity of DOFL is enhanced in the presence of CB7, as tested against four pathogenic bacteria; highest activity has been found towards B. cereus and E. coli, and lower activity towards S. aureus and S. typhi. The antibacterial activity of two additional second-generation fluoroquinones, i.e., norfloxacin and ofloxacin, has also been investigated in the absence as well as the presence of CB7 and compared with that of DOFL. In case of all drugs, the minimum inhibitory concentration (MIC) was reduced 3-5 fold in the presence of CB7. The extended shelf-life (antibacterial activity over time) of the fluoroquinone drugs in the presence of CB7, irrespective of four types of bacteria, can be attributed to the enhanced photostability of their CB7 complexes, which can act as better antibiotics with a longer expiry date than uncomplexed D...Continue Reading

References

Feb 1, 1989·Antimicrobial Agents and Chemotherapy·D T Chu, P B Fernandes
Apr 19, 2003·The Journal of Antimicrobial Chemotherapy·A M Emmerson, A M Jones
Jul 24, 2003·Chemical Society Reviews·Angelo Albini, Sandra Monti
May 12, 2005·Angewandte Chemie·Jyotirmayee Mohanty, Werner M Nau
Jan 12, 2010·Journal of the American Chemical Society·Sharmistha Dutta ChoudhuryAchikanath C Bhasikuttan
Jun 30, 2011·Chemical Communications : Chem Comm·Achikanath C BhasikuttanJyotirmayee Mohanty
Jul 16, 2011·Chemical Communications : Chem Comm·Nilotpal BarooahJyotirmayee Mohanty
Feb 14, 2012·Advanced Drug Delivery Reviews·Indrajit Ghosh, Werner M Nau
Mar 6, 2012·The Journal of Physical Chemistry. B·Nilotpal BarooahAchikanath C Bhasikuttan
Mar 27, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·George Psomas, Dimitris P Kessissoglou
Jun 28, 2013·Angewandte Chemie·Kai LiuXi Zhang
Sep 14, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina Uivarosi
Mar 22, 2014·Soft Matter·Sharmistha Dutta ChoudhuryJyotirmayee Mohanty
Jun 3, 2014·The Journal of Physical Chemistry. B·Nilotpal BarooahAchikanath C Bhasikuttan
Oct 16, 2014·Chemical Society Reviews·Khaleel I Assaf, Werner M Nau
Feb 7, 2015·The Journal of Physical Chemistry. B·Meenakshi N ShindeJyotirmayee Mohanty
Jul 22, 2015·Chemical Communications : Chem Comm·Nilotpal BarooahAchikanath C Bhasikuttan
Aug 21, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Meenakshi N ShindeJyotirmayee Mohanty
Aug 27, 2015·Angewandte Chemie·Haotian BaiShu Wang
Nov 14, 2015·Chemical Reviews·Steven J BarrowOren A Scherman
Nov 30, 2016·Chemistry, an Asian Journal·Nilotpal BarooahJyotirmayee Mohanty
May 24, 2017·Journal of the American Chemical Society·Ngoc D B LeVincent M Rotello
Jul 22, 2017·Chemical Communications : Chem Comm·Silvia SonziniChristopher F van der Walle
Aug 5, 2017·Physical Chemistry Chemical Physics : PCCP·V S KalyaniJ Mohanty
Sep 19, 2017·Chemistry : a European Journal·Michael Å PetersenMichael Pittelkow

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Citations

Feb 14, 2019·Physical Chemistry Chemical Physics : PCCP·Zsombor MiskolczyLászló Biczók
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huifang LiuYong Shin
May 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lisa J WhiteJennifer R Hiscock
Mar 5, 2020·Organic & Biomolecular Chemistry·Khaleel I AssafWerner M Nau
Oct 2, 2019·Frontiers in Chemistry·Debapratim DasWerner M Nau
Oct 29, 2020·Physical Chemistry Chemical Physics : PCCP·Sharmistha Dutta Choudhury, Haridas Pal
Apr 2, 2021·ACS Applied Materials & Interfaces·Priyanka RuzJyotirmayee Mohanty

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Methods Mentioned

BETA
Fluorescence
fluorescence titration
isothermal titration calorimetry
fluorescence titrations
NMR

Software Mentioned

Gaussian 09
Origin

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