A supramolecular microenvironment strategy for transition metal catalysis

Science
David M KaphanF Dean Toste

Abstract

A self-assembled supramolecular complex is reported to catalyze alkyl-alkyl reductive elimination from high-valent transition metal complexes [such as gold(III) and platinum(IV)], the central bond-forming elementary step in many catalytic processes. The catalytic microenvironment of the supramolecular assembly acts as a functional enzyme mimic, applying the concepts of enzymatic catalysis to a reactivity manifold not represented in biology. Kinetic experiments delineate a Michaelis-Menten-type mechanism, with measured rate accelerations (k(cat)/k(uncat)) up to 1.9 × 10(7) (here k(cat) and k(uncat) are the Michaelis-Menten enzymatic rate constant and observed uncatalyzed rate constant, respectively). This modality has further been incorporated into a dual catalytic cross-coupling reaction, which requires both the supramolecular microenvironment catalyst and the transition metal catalyst operating in concert to achieve efficient turnover.

References

Dec 22, 2005·Angewandte Chemie·Dorothea FiedlerKenneth N Raymond
Nov 11, 2009·Science·Vincent Lavallo, Robert H Grubbs
May 7, 2010·Journal of the American Chemical Society·Courtney J HastingsKenneth N Raymond
Jul 24, 2010·Nature Chemistry·Jurjen Meeuwissen, Joost N H Reek
Apr 27, 2011·Journal of the American Chemical Society·Z Jane WangF Dean Toste
Apr 21, 2012·Chemical Science·Anna E Allen, David W C Macmillan
May 11, 2012·Angewandte Chemie·Carin C C Johansson SeechurnVictor Snieckus
Jul 11, 2012·Angewandte Chemie·Amaruka HazariJohn E Bercaw
Oct 17, 2012·Journal of the American Chemical Society·William M Hart-CooperKenneth N Raymond
Jun 25, 2013·Journal of the American Chemical Society·Allegra L Liberman-MartinT Don Tilley
Oct 31, 2013·Journal of the American Chemical Society·Shin Takemoto, Vladimir V Grushin
Feb 24, 2015·Nature Chemistry·Q Zhang, K Tiefenbacher
Apr 22, 2015·Chemical Reviews·Casey J BrownKenneth N Raymond

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Citations

Feb 20, 2016·Nature Chemistry·Richard J Hooley
Jan 20, 2016·Science·KaKing Yan, Makoto Fujita
Jun 7, 2016·Journal of the American Chemical Society·Chuyang ChengJ Fraser Stoddart
Jun 23, 2016·Angewandte Chemie·C Rose KennedyEric N Jacobsen
Jun 29, 2016·Journal of the American Chemical Society·Michael J BurkePaul J Lusby
Jul 28, 2016·Journal of the American Chemical Society·Mark D LevinF Dean Toste
Aug 16, 2016·Journal of the American Chemical Society·Zhichang LiuJ Fraser Stoddart
Aug 20, 2016·Chemistry : a European Journal·Anne C H JansJoost N H Reek
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mingming ZhangPeter J Stang
Oct 11, 2016·Chemistry : a European Journal·Shinnosuke HoriuchiKeisuke Umakoshi
Oct 26, 2016·Chemistry : a European Journal·Guoliang LiuMaochun Hong
Dec 21, 2016·Journal of the American Chemical Society·Haxel Lionel OzoresJuan R Granja
Feb 24, 2017·The Journal of Organic Chemistry·Wanjun GongSimin Liu
Mar 16, 2017·Chemical Communications : Chem Comm·Hong-Yu ChenJiao-Bing Wang
May 31, 2017·Journal of the American Chemical Society·Xiao-Zhen LiQing-Fu Sun
Jun 27, 2017·Chemical Communications : Chem Comm·Yu WangXiaoyu Cao
Jul 4, 2017·Chemical Communications : Chem Comm·Yuchen YaoGeorge R Newkome
Feb 15, 2018·Nature Communications·Dipak SamantaRafal Klajn
Sep 12, 2017·Angewandte Chemie·Luca RocchigianiManfred Bochmann
Aug 18, 2017·Chemistry : a European Journal·Bijan RoyPartha Sarathi Mukherjee
Oct 28, 2017·Chemical Communications : Chem Comm·Chen ZhangJerry L Atwood
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zhixuan ZhouPeter J Stang
Apr 15, 2018·Chemistry : a European Journal·Luca RocchigianiManfred Bochmann
Jun 20, 2018·Chemistry : a European Journal·Imtiyaz Ahmad BhatPartha Sarathi Mukherjee
Aug 5, 2018·Chemistry : a European Journal·Chunxia TanYong Cui
Apr 11, 2019·Chemical Communications : Chem Comm·Liang LiangDan Li
Apr 16, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Thi V TranLoi H Do
Jun 15, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Li LiFeng Li
Jul 25, 2019·Chemical Society Reviews·Yu FangHong-Cai Zhou

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